Objective Myofiber necrosis without prominent inflammation is a nonspecific finding in patients
with dystrophies and toxic or immune‐mediated myopathies. However, the etiology of a …

Although pigment epithelium-derived factor (PEDF) is a neurotrophic factor that may aid the
development, differentiation, and survival of adjacent neural retinae, the wider distribution of …

Objective To devise and test a system with which to evaluate abnormalities on muscle biopsy
samples obtained from children diagnosed with juvenile dermatomyositis (DM). Methods …

Objective Activation of the type 1 interferon (IFN1) pathway is a prominent feature of
dermatomyositis (DM) muscle and may play a role in the pathogenesis of this disease. However, the …

Objectives Myositis is a heterogeneous family of diseases that includes dermatomyositis (DM),
antisynthetase syndrome (AS), immune-mediated necrotising myopathy (IMNM), inclusion …

Objective. Individual dermatomyositis (DM)-associated autoantibodies are associated with
distinct clinical phenotypes. This study was undertaken to explore the association of these …

Objective To define the clinical features of myositis patients with anti-PM/Scl-75 and/or anti-PM/Scl-100
autoantibodies at disease onset and during the course of disease and compare …

Objective In the context of clinical evaluations performed on our prospective myositis cohort,
we noted a striking association of severe cardiac disease in myositis patients with anti-…

Multifocal motor neuroparrhy (MMN) is a progressive disorder producing asymmetrical
weakness and muscle wasting. Case reports suggest that patients with MMN improve after …

Sporadic inclusion body myositis (IBM) is the most common acquired muscle disease in
adults over age 50, yet it remains unclear whether the disease is primarily driven by T cell–…