Childhood nephrotic syndromes are most commonly caused by one of two idiopathic diseases:
minimal-change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (…

All progressive renal diseases are the consequence of a process of destructive fibrosis. This
review will focus on tubulointerstitial fibrosis, the pathophysiology of which will be divided …

Progressive interstitial fibrosis accompanied by loss of renal tubules and interstitial capillaries
typifies all progressive renal diseases. Dynamic and complex, the process evidently …

Monocyte-derived macrophages can determine the outcome of the immune response and
whether this response contributes to tissue repair or mediates tissue destruction. In addition to …

The pathogenic mechanisms that lead to chronic kidney disease (CKD) converge on a
common pathway that results in progressive interstitial fibrosis, peritubular capillary loss with …

… Eddy et air Interstitial inflammation and renal fibrosis … EDDY A: Protein restriction reduces
transforming growth factor f3 and interstitial fibrosis in nephrotic syndrome. Am J Physiol 266: …

Objective. The development of this review article evolved from a National Kidney Foundation
consensus conference on recent advances in the importance of evaluating and treating …

In 1984, Loskutoff et al.(1) purified plasminogen activator inhibitor-1 (PAI-1) from conditioned
media of cultured endothelial cells. This 50-kd glycoprotein is the primary physiologic …

PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Background
Progressive renal disease is characterized by the induction of plasminogen activator inhibitor-1 (…

The common pathogenetic pathway of progressive injury in patients with chronic kidney
disease (CKD) is epitomized as normal kidney parenchymal destruction due to scarring (fibrosis)…