[HTML][HTML] Raising concerns about the Sepsis-3 definitions

…, C Paolillo, E Picetti, T Pintar, A Ponce-de-Leon… - World Journal of …, 2018 - Springer
The Global Alliance for Infections in Surgery appreciates the great effort of the task force
who derived and validated the Sepsis-3 definitions and considers the new definitions an …

[PDF][PDF] Tuberculosis activa en una cohorte de reclusos infectados por VIH en una cárcel de la Ciudad de México: características clínicas y epidemiológicas

…, F Badial-Hernández, A Ponce-de-León… - salud pública de …, 2012 - SciELO Public Health
OBJETIVO: Determinar las características clínicas y epidemiológicas de los casos con
tuberculosis (TB) activa en población de cárceles con VIH, que se ve especialmente afectada por …

Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis

…, MD Cave, A Ponce de León… - Antimicrobial agents …, 2006 - Am Soc Microbiol
The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative
isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and ndh. …

Global Phylogeny of Mycobacterium tuberculosis Based on Single Nucleotide Polymorphism (SNP) Analysis: Insights into Tuberculosis Evolution, Phylogenetic …

…, J Sifuentes-Osornio, A Ponce de León… - Journal of …, 2006 - Am Soc Microbiol
We analyzed a global collection of Mycobacterium tuberculosis strains using 212 single
nucleotide polymorphism (SNP) markers. SNP nucleotide diversity was high (average across all …

Association of diabetes and tuberculosis: impact on treatment and post-treatment outcomes

…, J Sifuentes-Osornio, A Ponce-de-León - Thorax, 2013 - thorax.bmj.com
Objective To determine the clinical consequences of pulmonary tuberculosis (TB) among
patients with diabetes mellitus (DM). Methods We conducted a prospective study of patients …

[HTML][HTML] Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

…, NR Mejía-Domínguez, A Ponce-de-León… - Scientific reports, 2021 - nature.com
We identified the main changes in serum metabolites associated with severe (n = 46) and
mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The …

[HTML][HTML] In-hospital mortality from severe COVID-19 in a tertiary care center in Mexico City; causes of death, risk factors and the impact of hospital saturation

…, KM Tamez-Flores, E Ochoa-Hein, A Ponce-de-Leon… - PloS one, 2021 - journals.plos.org
Background As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
has remained in Latin America, Mexico has become the third country with the highest …

[HTML][HTML] B cell subsets as severity-associated signatures in COVID-19 patients

…, V Ortiz-Navarrete, A Ponce-de-Leon… - Frontiers in …, 2020 - frontiersin.org
Background SARS-CoV-2 infection represents a global health problem that has affected
millions of people. The fine host immune response and its association with the disease course …

Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial

JA Maertens, G Rahav, DG Lee, A Ponce-de-León… - The Lancet, 2021 - thelancet.com
Background Voriconazole has been recommended as primary treatment for patients with
invasive aspergillosis. Intravenous and tablet formulations of posaconazole that have improved …

[HTML][HTML] Clinical and epidemiological characteristics of patients diagnosed with COVID-19 in a tertiary care center in Mexico City: a prospective cohort study

…, A Ponce-de-León - Revista de …, 2020 - scielo.org.mx
Background: Regional information regarding the characteristics of patients with coronavirus
disease (COVID)-19 is needed for a better understanding of the pandemic. Objective: The …