[PDF][PDF] Baricitinib, methotrexate, or combination in patients with rheumatoid arthritis and no or limited prior disease‐modifying antirheumatic drug treatment

…, C Ramos‐Remus, A Spindler… - Arthritis & …, 2017 - Wiley Online Library
Objective We undertook this phase III study to evaluate baricitinib, an orally administered
JAK‐1/JAK‐2 inhibitor, as monotherapy or combined with methotrexate (MTX) compared to …

Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial

…, CA Silva, E Silverman, A Spindler… - Annals of the …, 2015 - ard.bmj.com
Objective To evaluate the interleukin-6 receptor inhibitor tocilizumab for the treatment of
patients with polyarticular-course juvenile idiopathic arthritis (pcJIA). Methods This three-part, …

Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: results from a randomized, double‐blind, phase III study

EF Mysler, AJ Spindler, R Guzman, M Bijl… - Arthritis & …, 2013 - Wiley Online Library
Objective To investigate the efficacy and safety of ocrelizumab in patients with class III/IV
lupus nephritis (LN). Methods Patients were randomized 1:1:1 to receive placebo, 400 mg …

Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial

…, O Synoverska, TV Ting, CA Mendoza, A Spindler… - The Lancet, 2021 - thelancet.com
Background Tofacitinib is an oral Janus kinase inhibitor. This trial assessed the efficacy and
safety of tofacitinib versus placebo in patients with polyarticular course juvenile idiopathic …

Sifalimumab, a human anti–interferon‐α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose‐escalation study

M Petri, DJ Wallace, A Spindler… - Arthritis & …, 2013 - Wiley Online Library
Objective To evaluate the safety and tolerability of multiple intravenous (IV) doses of
sifalimumab in adults with moderate‐to‐severe systemic lupus erythematosus (SLE). Methods In …

Accuracy of anti–ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta‐analysis

…, G Morozzi, G Sanna, AJ Spindler… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To quantitatively evaluate the diagnostic accuracy of antibodies to ribosomal P
proteins (anti‐P) for neuropsychiatric systemic lupus erythematosus (NPSLE) in general, for …

Efficacy and safety of an interleukin 6 monoclonal antibody for the treatment of systemic lupus erythematosus: a phase II dose-ranging randomised controlled trial

…, V Strand, JT Merrill, S Popa, AJ Spindler… - Annals of the …, 2017 - ard.bmj.com
Objectives This phase II trial evaluated the efficacy and safety of an interleukin (IL) 6 monoclonal
antibody for systemic lupus erythematosus (SLE). Methods Patients with active disease …

Safety and tolerability of subcutaneous sarilumab and intravenous tocilizumab in patients with rheumatoid arthritis

…, N Liu, A Paccaly, R Wu, A Spindler - …, 2019 - academic.oup.com
Objective Safety and efficacy of mAbs blocking the IL-6 receptor have been established in
RA. This is the first analysis examining safety and tolerability of sarilumab and tocilizumab …

Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial

…, P Quartier, N Okamoto, I Foeldvari, A Spindler… - The Lancet, 2023 - thelancet.com
Background Juvenile idiopathic arthritis can be refractory to some or all treatment regimens,
therefore new medications are needed to treat this population. This trial assessed the …

Prevalence of rheumatoid arthritis in Tucumán, Argentina.

A Spindler, V Bellomio, A Berman, E Lucero… - The Journal of …, 2002 - jrheum.org
OBJECTIVE: To ascertain the prevalence of rheumatoid arthritis (RA) in Tucumán, Argentina.
METHODS: The study was conducted between January 1, 1998, and December 31, 1999, …