Objective To identify novel autoantibodies specific for dermatomyositis (DM), especially those
specific for clinically amyopathic DM (C‐ADM). Methods Autoantibodies were analyzed by …

Fatty acid synthesis in the central nervous system is implicated in the control of food intake
and energy expenditure. An intermediate in this pathway, malonyl-CoA, mediates these effects…

Autoantibodies to five of the aminoacyl-transfer RNA (tRNA) synthetases have been described,
and each is associated with a syndrome of inflammatory myopathy with interstitial lung …

The Ku protein is an autoantigen that consists of 70- and 80-kDa polypeptides. It associates
with double-stranded DNA at free ends. In the present study, we examined the ability of anti-…

Objective We have previously described anti‐KS autoantibodies and provided evidence that
they are directed against asparaginyl–transfer RNA (tRNA) synthetase (AsnRS). The aim of …

While the brain does not utilize fatty acids as a primary energy source, recent evidence shows
that intermediates of fatty acid metabolism serve as hypothalamic sensors of energy status…

Importance of the field: Inositol polyphosphate 5-phosphatase (SHIP2) is an important
negative regulator of intracellular phosphatidylinositol phosphate, a key second messenger of …

Anti-Ku (p70/p80) autoantibodies in patients with scleroderma-polymyositis overlap syndrome
recognize a 70-kDa/80-kDa protein heterodimer which binds to terminal regions of double-…

To elucidate the clinical and histopathological features associated with autoantibodies to the
signal recognition particle (SRP), we have studied 23 Japanese patients with this specificity …

… Shinji Sato, MD; Michito Hirakata, MD; Masataka Kuwana, MD; Kunio Nakamura, MD;
Akira Suwa, MD; Shinichi Inada, MD; Tsuneyo Mimori, MD; Yasuo Ikeda, MD. … MIMORIT …