Trajectories of kidney function in diabetes: a clinicopathological update
…, M Yamanouchi, T Toyama, A Hara… - Nature Reviews …, 2021 - nature.com
Diabetic nephropathy has been traditionally diagnosed based on persistently high albuminuria
and a subsequent decline in glomerular filtration rate (GFR), which is widely recognized …
and a subsequent decline in glomerular filtration rate (GFR), which is widely recognized …
Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy
…, K Kitagawa, S Kokubo, M Kobayashi, A Hara… - American Journal of …, 2005 - Elsevier
Background: The involvement of mitogen-activated protein kinase (MAPK) in human diabetic
nephropathy has not been fully investigated. Methods: The presence of cells positive for the …
nephropathy has not been fully investigated. Methods: The presence of cells positive for the …
[HTML][HTML] The outcome and a new ISN/RPS 2003 classification of lupus nephritis in Japanese
H Yokoyama, T Wada, A Hara, J Yamahana, I Nakaya… - Kidney international, 2004 - Elsevier
… Author links open overlay panel Hitoshi Yokoyama , Takashi Wada , Akinori Hara , Junya
Yamahana , Izaya Nakaya , Motoo Kobayashi , Kiyoki Kitagawa , Satoshi Kokubo , Yasunori …
Yamahana , Izaya Nakaya , Motoo Kobayashi , Kiyoki Kitagawa , Satoshi Kokubo , Yasunori …
Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy
…, K Furuichi, T Toyama, S Kitajima, A Hara… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE We evaluated the structural-functional relationships and the prognostic factors
for renal events, cardiovascular events, and all-cause mortality in type 2 diabetic patients with …
for renal events, cardiovascular events, and all-cause mortality in type 2 diabetic patients with …
Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes
…, K Iseki, S Araki, T Ninomiya, S Hara… - Clinical and …, 2014 - Springer
Background The number of patients suffering from diabetic nephropathy resulting in end-stage
kidney disease is increasing worldwide. In clinical settings, there are limited data …
kidney disease is increasing worldwide. In clinical settings, there are limited data …
Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): a phase …
…, N Takahashi, H Imamura, N Tatsumoto, A Hara… - The Lancet …, 2014 - thelancet.com
Background The prognosis for locally advanced gastric cancer is poor despite advances in
adjuvant chemotherapy. We did the Stomach cancer Adjuvant Multi-Institutional group Trial (…
adjuvant chemotherapy. We did the Stomach cancer Adjuvant Multi-Institutional group Trial (…
Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury
…, T Wada, Y Iwata, S Kokubo, A Hara… - Critical care …, 2006 - journals.lww.com
Objective: Ischemia-reperfusion injury is known to cause organ failure, but the mechanisms
of pathogenesis remain unclear. Inflammation is a factor in tissue destruction in ischemia …
of pathogenesis remain unclear. Inflammation is a factor in tissue destruction in ischemia …
[HTML][HTML] Gut microbiota–derived D-serine protects against acute kidney injury
…, Y Shinozaki, A Sagara, T Miyagawa, A Hara… - JCI insight, 2018 - ncbi.nlm.nih.gov
Gut microbiota–derived metabolites play important roles in health and disease. D–amino acids
and their L-forms are metabolites of gut microbiota with distinct functions. In this study, we …
and their L-forms are metabolites of gut microbiota with distinct functions. In this study, we …
Nonproteinuric versus proteinuric phenotypes in diabetic kidney disease: a propensity score–matched analysis of a nationwide, biopsy-based cohort study
…, K Furuichi, J Hoshino, T Toyama, A Hara… - Diabetes …, 2019 - Am Diabetes Assoc
OBJECTIVE Clinicopathological characteristics, renal prognosis, and mortality in patients
with type 2 diabetes and reduced renal function without overt proteinuria are scarce. …
with type 2 diabetes and reduced renal function without overt proteinuria are scarce. …
[HTML][HTML] Blockade of VEGF accelerates proteinuria, via decrease in nephrin expression in rat crescentic glomerulonephritis
A Hara, T Wada, K Furuichi, N Sakai, H Kawachi… - Kidney international, 2006 - Elsevier
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that maintains the
glomerular and peritubular capillary (PTC) network in the kidney. The soluble form of the …
glomerular and peritubular capillary (PTC) network in the kidney. The soluble form of the …