Integrated molecular analysis of adult T cell leukemia/lymphoma

…, SS Yoon, K Tobinai, Y Miyazaki, A Takaori-Kondo… - Nature …, 2015 - nature.com
Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here we …

[HTML][HTML] Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

…, Y Horisawa, K Yoshimura, A Takaori-Kondo… - Nature, 2022 - nature.com
During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations
have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (…

[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

…, S Mitsunaga, T Ueno, K Shirakawa, A Takaori-Kondo… - Nature, 2022 - nature.com
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

[HTML][HTML] Neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine serum

…, I Kimura, K Shirakawa, A Takaori-Kondo… - … England Journal of …, 2021 - Mass Medical Soc
Neutralization of the SARS-CoV-2 Mu Variant The mu variant of SARS-CoV-2 was 10.6 times
as resistant to neutralization by serum samples obtained from persons who had recovered …

[HTML][HTML] APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells

…, M Kobayashi, N Kadowaki, A Takaori-Kondo - Scientific reports, 2012 - nature.com
Human APOBEC3 proteins play pivotal roles in intracellular defense against viral infection
by catalyzing deamination of cytidine residues, leading to base substitutions in viral DNA. …

[PDF][PDF] Epigenetic variation between human induced pluripotent stem cell lines is an indicator of differentiation capacity

…, K Okita, A Watanabe, A Takaori-Kondo… - Cell stem cell, 2016 - cell.com
Variation in the differentiation capacity of induced pluripotent stem cells (iPSCs) to specific
lineages is a significant concern for their use in clinical applications and disease modeling. …

[HTML][HTML] Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function

M Kobayashi, A Takaori-Kondo, Y Miyauchi… - Journal of Biological …, 2005 - ASBMB
The human immunodeficiency virus type 1 (HIV-1) virion infectivity factor (Vif) overcomes the
antiviral activity of APOBEC3G to protect HIV-1 DNA from G-to-A hypermutation. Vif targets …

Molecular international prognostic scoring system for myelodysplastic syndromes

…, L Palomo, MG Della Porta, A Takaori-Kondo… - NEJM …, 2022 - evidence.nejm.org
Background Risk stratification and therapeutic decision-making for myelodysplastic
syndromes (MDS) are based on the International Prognostic Scoring System–Revised (IPSS-R), …

[PDF][PDF] Virological characteristics of the SARS-CoV-2 Omicron BA. 2 spike

…, S Sakao, T Suzuki, T Ueno, A Takaori-Kondo… - Cell, 2022 - cell.com
Soon after the emergence and global spread of the SARS-CoV-2 Omicron lineage BA.1,
another Omicron lineage, BA.2, began outcompeting BA.1. The results of statistical analysis …

Singlet oxygen is essential for neutrophil extracellular trap formation

Y Nishinaka, T Arai, S Adachi, A Takaori-Kondo… - Biochemical and …, 2011 - Elsevier
Neutrophil extracellular traps (NETs) that bind invading microbes are pivotal for innate host
defense. There is a growing body of evidence for the significance of NETs in the …