[PDF][PDF] A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

AB Begovich, VEH Carlton, LA Honigberg… - The American Journal of …, 2004 - cell.com
… Email: Ann.Begovich@celeradiagnostics.com * These authors contributed equally to this …
neutrophils expressing the most PTPN22 message and B cells and CD4+ T cells expressing …

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

…, EW Karlson, REM Toes, N de Vries, AB Begovich… - Nature …, 2010 - nature.com
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

…, A Menter, GM Lathrop, CA Wise, AB Begovich… - Nature …, 2009 - nature.com
Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To
identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases …

[PDF][PDF] A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes

…, MF Leppert, GG Krueger, AB Begovich - The American Journal of …, 2007 - cell.com
We performed a multitiered, case-control association study of psoriasis in three independent
sample sets of white North American individuals (1,446 cases and 1,432 controls) with …

[PDF][PDF] Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE

…, PM Gaffney, KL Moser, M Petri, AB Begovich… - The American Journal of …, 2004 - cell.com
We genotyped 525 independent North American white individuals with systemic lupus
erythematosus (SLE) for the PTPN22 R620W polymorphism and compared the results with data …

[PDF][PDF] Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple …

…, J Novitzke, M Kern, KL Moser, AB Begovich… - The American Journal of …, 2005 - cell.com
Autoimmune disorders constitute a diverse group of phenotypes with overlapping features
and a tendency toward familial aggregation. It is likely that common underlying genes are …

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

…, M Seielstad, REM Toes, EW Karlson, AB Begovich… - Nature …, 2008 - nature.com
To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis
of two published genome-wide association (GWA) studies totaling 3,393 cases and …

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

…, EW Karlson, REM Toes, N de Vries, AB Begovich… - Nature …, 2009 - nature.com
To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

…, LW Moreland, SL Bridges Jr, G Xie, AB Begovich… - Nature …, 2009 - nature.com
We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and
4,504 controls from North America and identified an association at the REL locus, encoding c-…

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis

…, F Briggs, BCA Cree, AB Begovich… - Human molecular …, 2006 - academic.oup.com
Variation in major histocompatibility complex genes on chromosome 6p21.3, specifically the
human leukocyte antigen HLA-DR2 or DRB1*1501-DQB1*0602 extended haplotype, …