User profiles for ALAN L. EPSTEIN

Alan L Epstein

Keck School of Medicine of USC
Verified email at usc.edu
Cited by 12052

Cloning the chromosomal breakpoint of t (14; 18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18

…, P Goldman, JJ Wright, OW McBride, AL Epstein… - Cell, 1985 - cell.com
Specific chromosomal translocations found in distinct neoplasms suggest that genes that
flank such breakpoints play a critical role in transformation. We have characterized the t(14;18)(…

Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells

MG Lechner, DJ Liebertz, AL Epstein - The Journal of Immunology, 2010 - journals.aai.org
Tumor immune tolerance can derive from the recruitment of suppressor cell populations,
including myeloid-derived suppressor cells (MDSCs). In cancer patients, increased MDSCs …

EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts

J Zucman, O Delattre, C Desmaze, AL Epstein… - Nature …, 1993 - nature.com
The genes involved in the t(12;22)(q13;q12) translocation found recurrently in malignant
melanoma of soft parts have been characterized and shown to form, in four cases studied, …

Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases

…, G Carlson, MG Lechner, AL Epstein - Plastic and …, 2015 - journals.lww.com
Background: The first silicone breast implant was inserted in 1962. In 1997, the first case of
anaplastic large cell lymphoma (ALCL) in association with a silicone breast implant was …

Immunogenicity of murine solid tumor models as a defining feature of in vivo behavior and response to immunotherapy

…, CH Church, JR Ohlfest, P Hu, AL Epstein - Journal of …, 2013 - journals.lww.com
Immune profiling has been widely used to probe mechanisms of immune escape in cancer
and identify novel targets for therapy. Two emerging uses of immune signatures are to …

[HTML][HTML] Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co …

…, B Bingham, N Arger, T Woo, AL Epstein - Journal of translational …, 2011 - Springer
Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell
subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of …

Biomarkers provide clues to early events in the pathogenesis of breast implant-associated anaplastic large cell lymphoma

…, WP Adams Jr, GS Brody, AL Epstein - Aesthetic surgery …, 2016 - academic.oup.com
Almost 200 women worldwide have been diagnosed with breast implant-associated
anaplastic large cell lymphoma (BIA-ALCL). The unique location and specific lymphoma type …

[HTML][HTML] Genetically engineered cell-derived nanoparticles for targeted breast cancer immunotherapy

…, T Hou, M Han, G Smbatyan, JE Lang, AL Epstein… - Molecular therapy, 2020 - cell.com
Exosomes are nanosized membranous vesicles secreted by a variety of cells. Due to their
unique and pharmacologically important properties, cell-derived exosome nanoparticles have …

MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In Vitro

…, MG Lechner, JK Jang, JS LoPresti, AL Epstein - Clinical Cancer …, 2014 - AACR
Purpose: To evaluate MHC class I expression on papillary thyroid cancer (PTC) and
analyze changes in MHC expression and associated immune activation with current and …

Survival Signals and Targets for Therapy in Breast Implant–Associated ALK Anaplastic Large Cell Lymphoma

…, RB Sevell, JK Jang, GS Brody, AL Epstein - Clinical Cancer …, 2012 - AACR
Purpose: Anaplastic lymphoma kinase (ALK)–negative, T-cell, anaplastic, non–Hodgkin
lymphoma (T-ALCL) in patients with textured saline and silicone breast implants is a recently …