User profiles for AKIYOSHI NAKAYAMA

Akiyoshi NAKAYAMA

Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical …
Verified email at ndmc.ac.jp
Cited by 3323

[HTML][HTML] Decreased extra-renal urate excretion is a common cause of hyperuricemia

K Ichida, H Matsuo, T Takada, A Nakayama… - Nature …, 2012 - nature.com
ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which
raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate '…

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population

…, K Ichida, T Nakamura, A Nakayama… - Science translational …, 2009 - science.org
Gout based on hyperuricemia is a common disease with a genetic predisposition, which
causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on …

[PDF][PDF] Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia

H Matsuo, T Chiba, S Nagamori, A Nakayama… - The American Journal of …, 2008 - cell.com
Renal hypouricemia is an inherited disorder characterized by impaired renal urate (uric acid)
reabsorption and subsequent low serum urate levels, with severe complications such as …

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

…, K Yamamoto, H Nakaoka, A Nakayama… - Annals of the …, 2016 - ard.bmj.com
Objective Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide
association studies (GWASs) of gout have been reported, they included self-reported gout …

[HTML][HTML] ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload

H Matsuo, A Nakayama, M Sakiyama, T Chiba… - Scientific reports, 2014 - nature.com
Gout is a common disease which results from hyperuricemia. We have reported that the
dysfunction of urate exporter ABCG2 is the major cause of renal overload (ROL) hyperuricemia, …

[HTML][HTML] Common dysfunctional variants in ABCG2 are a major cause of early-onset gout

H Matsuo, K Ichida, T Takada, A Nakayama… - Scientific reports, 2013 - nature.com
Gout is a common disease which mostly occurs after middle age, but more people nowadays
develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, …

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

A Nakayama, H Nakaoka, K Yamamoto… - Annals of the …, 2017 - ard.bmj.com
Objective A genome-wide association study (GWAS) of gout and its subtypes was performed
to identify novel gout loci, including those that are subtype-specific. Methods Putative …

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Y Kawamura, H Nakaoka, A Nakayama… - Annals of the …, 2019 - ard.bmj.com
Objective The first ever genome-wide association study (GWAS) of clinically defined gout
cases and asymptomatic hyperuricaemia (AHUA) controls was performed to identify novel gout …

[PDF][PDF] NPT1/SLC17A1 is a renal urate exporter in humans and its common gain‐of‐function variant decreases the risk of renal underexcretion gout

…, T Nishiyama, L Wei, A Nakayama… - Arthritis & …, 2015 - Wiley Online Library
Objective Serum uric acid (SUA) levels in humans are mainly regulated by urate transporters.
Recent genome‐wide association studies suggested that common variants of the human …

[HTML][HTML] Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

M Nakatochi, M Kanai, A Nakayama, A Hishida… - Communications …, 2019 - nature.com
Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated
loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects…