Leber’s hereditary optic neuropathy is a maternally inherited blinding disease caused as a
result of homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. It is …

1. Abstract The HELLP syndrome is a serious complication of pregnancy characterized by
hemolysis (H), elevated liver (EL) enzymes, and low platelet (LP) count that occurs in 0.2–0.6…

¶This study reports late surgical results obtained in 9 patients operated on for an epidermoid
cyst of the fourth ventricle. They represent 19/9% of all cases of epidermoids treated at our …

Tail data are often modelled by fitting a generalized Pareto distribution (GPD) to the exceedances
over high thresholds. In practice, a threshold $$u$$ is fixed and a GPD is fitted to the …

We describe the sources and routing of the Amazon River flood wave through a 2000‐km
reach of the main channel, between São Paulo de Olivença and Obidos, Brazil. The damped …

The Enhanced Recovery After Surgery (ERAS) is a model of care introduced in 1997 by a
group of general surgeons from Northern Europe led by Henrik Kehlet. The core of this …

The KEAP1/Nrf2 pathway is a master regulator of several redox-sensitive genes implicated
in resistance of tumor cells against chemotherapeutic drugs. Recent data suggest that …

Introduction Overexpression of the ERBB2 oncogene is observed in about 20% of human
breast tumors and is the consequence of increased transcription rates frequently associated …

Chronic intestinal pseudo-obstruction is a life-threatening condition of unknown pathogenic
mechanisms. Chronic intestinal pseudo-obstruction can be a feature of mitochondrial …

Objective To date, serum free testosterone measurement is considered to be the gold standard
for the diagnosis of hypogonadism in elderly males but it is not available to all subjects …