Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …

Here we describe the LifeTime Initiative, which aims to track, understand and target human
cells during the onset and progression of complex diseases, and to analyse their response to …

Epigenomics is the study of the physical modifications, associations and conformations of
genomic DNA sequences, with the aim of linking these with epigenetic memory, cellular …

In multicellular organisms, biological function emerges when heterogeneous cell types form
complex organs. Nevertheless, dissection of tissues into mixtures of cellular subpopulations …

Within the bone marrow, stem cells differentiate and give rise to diverse blood cell types and
functions. Currently, hematopoietic progenitors are defined using surface markers …

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can
be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous …

Chromosomes are the physical realization of genetic information and thus form the basis for
its readout and propagation. Here we present a high-resolution chromosomal contact map …

Large-scale chromosome structure and spatial nuclear arrangement have been linked to
control of gene expression and DNA replication and repair. Genomic techniques based on …

In gene expression data, a bicluster is a subset of the genes exhibiting consistent patterns
over a subset of the conditions. We propose a new method to detect significant biclusters in …

The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds
90% when diagnosed after age 65. Most cases arise without any detectable early symptoms …