Checkpoint blockade immunotherapy has received mainstream attention as a result of striking
and durable clinical responses in some patients with metastatic disease and a reasonable …

Regulatory T (T reg ) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving transplanted …

Abstract Knowledge of the basic mechanisms of the immune system as it relates to cancer
has been increasing rapidly. These developments have accelerated the translation of these …

Trophoblast invasion of the uterine extracellular matrix, a critical process of human implantation
and essential for fetal development, is a striking example of controlled invasiveness. To …

Purpose: Checkpoint inhibitors demonstrate salutary anticancer effects, including long-term
remissions. PD-L1 expression/amplification, high mutational burden, and mismatch repair …

The immune-modulating effects of radiotherapy (XRT) have gained considerable interest
recently, and there have been multiple reports of synergy between XRT and immunotherapy. …

Purpose: In the proper context, radiotherapy can promote antitumor immunity. It is unknown
if elective nodal irradiation (ENI), a strategy that irradiates tumor-associated draining lymph …

Purpose: To characterize the role of B cells on human papilloma virus (HPV)-associated
cancer patient outcomes and determine the effects of radiation and PD-1 blockade on B-cell …

T cell subsets are critically involved in the development of systemic autoimmunity and organ
inflammation in systemic lupus erythematosus (SLE). Each T cell subset function (such as …

Despite the promise of immune checkpoint inhibition (ICI), therapeutic responses remain
limited. This raises the possibility that standard of care treatments delivered in concert may …