The impact of inflammation on cognitive function in older adults: implications for healthcare practice and research
Accumulating evidence suggests that levels of inflammation, an immune response, increase
with age throughout the body and the brain. The effects of inflammation on the brain, both …
with age throughout the body and the brain. The effects of inflammation on the brain, both …
[HTML][HTML] Harnessing DNA double-strand break repair for cancer treatment
A Trenner, AA Sartori - Frontiers in oncology, 2019 - frontiersin.org
DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB being
sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher DSB …
sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher DSB …
New developments of the principle of vinylogy as applied to π-extended enolate-type donor systems
The principle of vinylogy states that the electronic effects of a functional group in a molecule
are possibly transmitted to a distal position through interposed conjugated multiple bonds. …
are possibly transmitted to a distal position through interposed conjugated multiple bonds. …
Human CtIP promotes DNA end resection
AA Sartori, C Lukas, J Coates, M Mistrik, S Fu, J Bartek… - Nature, 2007 - nature.com
In the S and G2 phases of the cell cycle, DNA double-strand breaks (DSBs) are processed
into single-stranded DNA, triggering ATR-dependent checkpoint signalling and DSB repair by …
into single-stranded DNA, triggering ATR-dependent checkpoint signalling and DSB repair by …
Disease‐modifying therapies and coronavirus disease 2019 severity in multiple sclerosis
…, A Bosco, A Gallo, A Zito, A Sartori… - Annals of …, 2021 - Wiley Online Library
Objective This study was undertaken to assess the impact of immunosuppressive and
immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID‐19) in people …
immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID‐19) in people …
An estimator for some binary-outcome selection models without exclusion restrictions
AE Sartori - Political Analysis, 2003 - cambridge.org
This article provides a new maximum-likelihood estimator for selection models with
dichotomous dependent variables when identical factors affect the selection equation and the …
dichotomous dependent variables when identical factors affect the selection equation and the …
[PDF][PDF] RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
…, V Borel, M Steger, A Tomas-Loba, AA Sartori… - Molecular cell, 2013 - cell.com
The appropriate execution of DNA double-strand break (DSB) repair is critical for genome
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …
CDK targets Sae2 to control DNA-end resection and homologous recombination
DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous
end-joining (NHEJ) and homologous recombination (HR) 1 . HR is the most accurate …
end-joining (NHEJ) and homologous recombination (HR) 1 . HR is the most accurate …
[HTML][HTML] New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing
…, M Shah, C Lee, TT Harkins, A Sartori… - Nature …, 2012 - nature.com
The Tyrolean Iceman, a 5,300-year-old Copper age individual, was discovered in 1991 on
the Tisenjoch Pass in the Italian part of the Ötztal Alps. Here we report the complete genome …
the Tisenjoch Pass in the Italian part of the Ötztal Alps. Here we report the complete genome …
Fermi-LAT observations of the gamma-ray burst GRB 130427A
The observations of the exceptionally bright gamma-ray burst (GRB) 130427A by the Large
Area Telescope aboard the Fermi Gamma-ray Space Telescope provide constraints on the …
Area Telescope aboard the Fermi Gamma-ray Space Telescope provide constraints on the …