IL-17 cytokines are expressed by a variety of cells and mediate host defence against extracellular
pathogens. IL-17 is upregulated at sites of inflammation and can synergize with other …

… Nirula, Ajay a ; Glaser, Scott M a ; Kalled, Susan L b ; Taylora, Frederick R b …
Correspondence to Ajay Nirula, Biogen Idec, 5200 Research Place, San Diego, CA 92130, USA …

Background Patients with underlying medical conditions are at increased risk for severe
coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over time, …

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus disease 2019 (Covid-19), which is most frequently mild yet can be severe and life-…

… Nirula had full access to all of the data in the study and take responsibility for the integrity of
the data and the accuracy of the data analysis. Drs Gottlieb and Nirula … Drs Nirula and Adams…

Background Early clinical studies suggested that the anti–interleukin-17 receptor A monoclonal
antibody brodalumab has efficacy in the treatment of psoriasis. Methods In two phase 3 …

Background We assessed the efficacy and safety of brodalumab, a human monoclonal
antibody against interleukin-17 receptor A (IL17RA), in a phase 2, randomized, double-blind, …

Advancements in Genome editing technologies have revolutionized the fields of functional
genomics and crop improvement. CRISPR/Cas9 (clustered regularly interspaced short …

Baricitinib is an oral Janus kinase ( JAK )1/ JAK 2 inhibitor approved for the treatment of
rheumatoid arthritis ( RA ) that was independently predicted, using artificial intelligence ( AI ) …

Importance Preventive interventions are needed to protect residents and staff of skilled
nursing and assisted living facilities from COVID-19 during outbreaks in their facilities. …