Diabetic nephropathy is a significant cause of chronic kidney disease and end-stage renal
failure globally. Much research has been conducted in both basic science and clinical …

Diabetic nephropathy is the leading cause of end-stage kidney disease worldwide but current
treatments remain suboptimal. This review examines the evidence for inflammation in the …

Regardless of the original causes and etiology, the progression to renal function declines
follows a final common pathway associated with tubulointerstitial injury, in which the proximal …

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1,
also known as γ chain (γc) deficiency] in 9 out of 10 patients by retrovirus-mediated γc …

The bacterium Escherichia coli O157:H7 is a worldwide threat to public health and has been
implicated in many outbreaks of haemorrhagic colitis, some of which included fatalities …

Chronic myeloid leukemia responds well to therapy targeting the oncogenic fusion protein
BCR-ABL1 in chronic phase, but is resistant to treatment after it progresses to blast crisis (BC). …

The HIF-1 transcription factor drives hypoxic gene expression changes that are thought to be
adaptive for cells exposed to a reduced-oxygen environment. For example, HIF-1 induces …

Background No systemic therapies have been approved for the treatment of advanced
cutaneous squamous-cell carcinoma. This cancer may be responsive to immune therapy, …

A simple yet highly reproducible method to fabricate metallic electrodes with nanometer
separation is presented. The fabrication is achieved by passing a large electrical current through …

Understanding the particle size distribution in the air and patterns of environmental contamination
of SARS-CoV-2 is essential for infection prevention policies. Here we screen surface …