[HTML][HTML] Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

BJE De Lange-Brokaar, A Ioan-Facsinay… - Osteoarthritis and …, 2012 - Elsevier
OBJECTIVE: Although osteoarthritis (OA) is considered a non-inflammatory condition, it is
widely accepted that synovial inflammation is a feature of OA. However, the role of immune …

Association between weight or body mass index and hand osteoarthritis: a systematic review

E Yusuf, RG Nelissen, A Ioan-Facsinay… - Annals of the …, 2010 - ard.bmj.com
Objective To investigate the association between weight or body mass index (BMI) and the
development of hand osteoarthritis. Methods Systematic review of observational studies. …

[HTML][HTML] An emerging player in knee osteoarthritis: the infrapatellar fat pad

A Ioan-Facsinay, M Kloppenburg - Arthritis research & therapy, 2013 - Springer
The role of inflammation in the development, progression, and clinical features of osteoarthritis
has become an area of intense research in recent years. This led to the recognition of …

Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

J Wang, A IoanFacsinay… - European journal of …, 2007 - Wiley Online Library
Foxp3 plays a key role in CD4 + CD25 + T reg cell function in mice and represents a specific
marker for these cells. Despite the strong association between FOXP3 expression and …

[PDF][PDF] FcγRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

A Ioan-Facsinay, SJ De Kimpe, SMM Hellwig… - Immunity, 2002 - cell.com
The high-affinity receptor for IgG, FcγRI, shares its capacity to bind IgG2a immune complexes
(IgG2a-IC) with the low-affinity receptor FcγRIII and complement factors, hampering the …

Anti–cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

…, D Van Der Woude, A IoanFacsinay… - … : Official Journal of …, 2009 - Wiley Online Library
Objective It has been suggested that anti–citrullinated protein antibodies (ACPAs) play an
important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic effects…

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

…, S Rantapää-Dahlqvist, A Ioan-Facsinay… - Annals of the …, 2010 - ard.bmj.com
Background Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the
development of rheumatoid arthritis (RA). Objective To investigate whether the recognition …

The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

…, G Van Osch, REM Toes, A Ioan-Facsinay - Annals of the …, 2011 - ard.bmj.com
Objectives Obesity is a risk factor for the development of osteoarthritis (OA) in hands and
knees. Adipose tissue can secrete different adipokines with powerful immunomodulatory effects…

Isotype distribution of anti–cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response

…, A IoanFacsinay… - … : Official Journal of …, 2006 - Wiley Online Library
Objective The evolution of the rheumatoid arthritis (RA)–specific anti–cyclic citrullinated
peptide (anti‐CCP) antibody response, as measured by the isotypes of anti‐CCP, has not been …

Antibodies to Porphyromonas gingivalis are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives

…, ED Ferucci, A Willemze, A Ioan-Facsinay… - The Journal of …, 2010 - jrheum.org
Objective. Anticitrullinated protein antibodies (ACPA) are relatively specific for rheumatoid
arthritis (RA), and predate disease. The oral pathogen Porphyromonas gingivalis may play a …