Several studies indicate that nonsteroidal anti-inflammatory drugs including indomethacin,
aspirin, sulindac, and piroxicam reduce the risk of colon cancer. Furthermore, nonsteroidal …

Gangliosides are sialic acid-containing glycosphingolipids that are present on all mammalian
plasma membranes where they participate in recognition and signaling activities. We have …

Synovial mesenchymal cells, matrix metalloproteinases (MMPs), and osteoclasts are the
three major players directly responsible for the pathogenesis of rheumatoid joint destruction. …

Peroxisome proliferator–activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily and have a dominant regulatory role in adipocyte and monocyte …

Endogenous DNA derived from the nuclei or mitochondria is released into the bloodstream
following cell damage or death. Extracellular DNA, called cell-free DNA (cfDNA), is …

Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by
diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects …

The mammalian clock genes, Period and Cryptochrome (Cry), regulate circadian rhythm.
We show that circadian rhythmicity and rhythmic expression of Period in the nuclei of …

Objective To examine the promoter activity and protein expression of the death receptor 3
gene DR3, a member of the apoptosis‐inducing Fas gene family, with particular reference to …

To inhibit arthritis upstream of inflammatory cytokine release and matrix metalloproteinase (MMP)
action, we designed de novo a small-molecule inhibitor of c-Fos/activator protein-1 (AP…

Objective. To compare tumor necrosis factor-α (TNF-α) inhibitors to nonbiological disease-modifying
antirheumatic drugs (DMARD) for the risk of serious infection in Japanese patients …