Aging is related to a number of functional and morphological changes leading to
progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), …

Computer-aided drug discovery techniques reduce the time and the costs needed to develop
novel drugs. Their relevance becomes more and more evident with the needs due to …

GSK-3 is a ubiquitously expressed serine/threonine kinase existing as GSK-3α and GSK-3β
isoforms, both active under basal conditions and inactivated upon phosphorylation by …

Developing automatic diagnostic tools for the early detection of skin cancer lesions in
dermoscopic images can help to reduce melanoma-induced mortality. Image segmentation is a …

A methodology based on matrix-assisted laser desorption ionization-time of flight mass
spectrometry of intact bacterial cells was used for rapid discrimination of 24 bacterial species, …

Sézary syndrome (SS) is an incurable leukemic variant of cutaneous T-cell lymphoma and
its pathogenesis is still unknown. Diagnosis/prognosis may strongly ameliorate the …

Background & Aims: Celiac disease is characterized by activation of HLA-DQ2/DQ8–restricted
intestinal gluten-specific CD4 + T cells. In particular, gluten becomes a better T-cell …

Amino acid propensities for secondary structures were used since the 1970s, when Chou and
Fasman evaluated them within datasets of few tens of proteins and developed a method to …

Significant future developments in the effective treatment of inflammatory diseases may arise
from non-toxic dual inhibitors of both cyclooxygenase and lipoxygenase pathways in the …

Background Pyoderma gangrenosum (PG) is a rare, neutrophilic, ulcerative skin disease
that is difficult to treat, especially when unresponsive to steroids. Objectives To determine …