Nicotinamide adenine dinucleotide (NAD + ) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD + is also an essential cofactor for non-redox NAD + -…

Water limitation affects all types of organisms at some stage during their life cycle; therefore,
many strategies have been selected through evolution to cope with water deficit, including …

The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with particular
risk for severe disease and death in older adults and in adults with age-related metabolic …

The late embryogenesis abundant (LEA) proteins are plant proteins that are synthesized at
the onset of desiccation in maturing seeds and in vegetative organs exposed to water deficit. …

Macrophages are able to polarize to proinflammatory M1 or alternative M2 states with distinct
phenotypes and physiological functions. How metabolic status regulates macrophage …

Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and
its associated diseases. However, the mechanism for this decline is unclear. Here, we show …

10.7554/eLife.11612.001 Macrophage activation/polarization to distinct functional states is
critically supported by metabolic shifts. How polarizing signals coordinate metabolic and …

Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance
on fatty acid metabolism and production of ketone bodies. We investigated whether an …

Macrophages are pleiotropic cells that assume a variety of functions depending on their
tissue of residence and tissue state. They maintain homeostasis as well as coordinate …

MicroRNAs (miRNAs) are small RNA molecules recognized as important regulators of gene
expression. Although plant miRNAs have been extensively studied in model systems, less is …