Radiation is used in the treatment of a broad range of malignancies. Exposure of normal tissue
to radiation may result in both acute and chronic toxicities that can result in an inability to …

The concept of transferring genes to tissues for clinical applications has been discussed for
nearly half a century, but our ability to manipulate genetic material via recombinant DNA …

The treatment of most patients with head and neck cancer includes ionizing radiation (IR).
Salivary glands in the IR field suffer significant and irreversible damage, leading to …

No conventional therapy exists for salivary hypofunction in surviving head and neck cancer
patients with Radiation Therapy Oncology Group late grade 2–3 toxicity. We conducted a …

Treatment for most patients with head and neck cancers includes ionizing radiation. A
consequence of this treatment is irreversible damage to salivary glands (SGs), which is …

Purpose: The nitroxide free radical, Tempol, was evaluated for potential differential radiation
protection of salivary glands and tumor using fractionated radiation. Mechanistic information …

Treatment of most head and neck cancers includes radiotherapy. Salivary glands (SGs) in
the irradiation (IR) field are irreversibly damaged resulting in severe hyposalivation. We …

Background: Sjögren’s syndrome (SS), an autoimmune exocrinopathy mainly affecting
lachrymal and salivary glands, results in ocular and oral dryness (keratoconjunctivitis sicca and …

Purpose: Optical coherence tomography (OCT) imaging was evaluated to determine if
radiation-induced mucosal damage could be noninvasively monitored in real time and correlated …

Purpose: Salivary glands are significantly affected when head and neck cancer patients are
treated by radiation. We evaluated the effect of human keratinocyte growth factor (hKGF) …