Background An urgent need exists in the United States to establish treatment goals in
psoriasis. Objective We aim to establish defined treatment targets toward which clinicians and …

… Dr Mandelin is on the advisory board for Horizon and the speakers’ bureau for Abbott/AbbVie,
Genentech, Pfizer, Sanofi/Genzyme, and UCB; he serves as a speaker for American …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

Objectives Electronic health records (EHR) can allow for the generation of large cohorts of
individuals with given diseases for clinical and genomic research. A rate-limiting step is the …

… Thereafter, tube formation was quantified using calcein-AM fluorescent dye (BD BioSciences)
diluted with HBSS and DMSO, according to the manufacturer’s instructions, for 30 min. …

Introduction The aim of this study was to quantify the number of T-helper (TH)-17 cells present
in rheumatoid arthritis (RA) synovial fluid (SF) and to determine the level of interleukin (IL)-…

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Macrophages are important mediators of chronic inflammation and are prominent in the
synovial lining and sublining of patients with rheumatoid arthritis (RA). Recently, we …

… Mandelin has received fees for serving on the speakers' bureaus of Abbott and UCB (less …
Mandelin has received fees for serving on the speakers' bureaus of Abbott and UCB (less than …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that is mediated, in part, by
proinflammatory factors produced by RA synovial tissue (ST) fibroblasts and macrophages, …