… Adam Raymakers generated the original idea for this study, conducted the systematic review,
and drafted and submitted the manuscript. John Mayo and Mark FitzGerald helped with the …

Background Changes to physiological parameters precede deterioration of ill patients. Early
warning and track and trigger systems (TTS) use routine physiological measurements with …

Inhaled corticosteroids (ICS) are commonly prescribed to COPD patients, particularly those
with more advanced stages of the disease. These patients are also at increased risk of lung …

Chimeric antigen receptor (CAR) T-cells are a cellular immunotherapy with remarkable
efficacy in treating multiple hematologic malignancies but they are associated with extremely …

Inhaled corticosteroids (ICSs) are often prescribed in patients with chronic obstructive pulmonary
disease (COPD). Their impact on the risk of lung cancer, a leading cause of mortality in …

Background Patients with COPD are often prescribed statin drugs due to the increased
prevalence of cardiovascular disease. There is considerable debate about the benefits conferred …

Background Criticisms have emerged that cancer medicines offer modest benefits at increasingly
high prices. Reimbursement decisions made by health technology assessment (HTA) …

Background Patients living with chronic obstructive pulmonary disease (COPD) are at an
increased risk of lung cancer. A common comorbidity of COPD is cardiovascular disease; as …

Importance The US lacks a systematic approach for aligning drug prices with clinical benefit,
and traditional cost-effectiveness analysis (CEA) faces political obstacles. The efficiency …

External genital warts (EGW) are a sexually transmitted infection caused by various strains
of human papillomavirus (HPV). Several studies have described the direct and indirect costs …