Background & Aims: Crohn’s disease (CD) is an immunologically mediated inflammatory
disease of the gastrointestinal tract. Due to a high morbidity and/or an increase in mortality in …

… Ann Traynor and Richard Burt wrote the treatment protocol and managed all patients
through transplantation and follow-up. They were assisted in rheumatological consultation and …

Multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis are immune-mediated
diseases that are responsive to suppression or modulation of the immune system. For …

Multiple sclerosis (MS) is a disease of the central nervous system characterized by immune-mediated
destruction of myelin. In patients with progressive deterioration, we have …

Objective To determine the safety and long‐term efficacy of immune ablation and autologous
hematopoietic stem cell transplantation (HSCT) in severe systemic lupus erythematosus (…

Chemoattractants such as N-formyl peptides, cleavage product of the fifth component of
complement (Ga), leukotriene B4 (LTBJ, platelet-activating factor (PAF), and crystal-induced …

Evans syndrome is a rare disorder characterized by combined autoimmune thrombocytopenia
(ITP) and autoimmune hemolytic anemia (AIHA). Standard treatments consist of …

Cyclic GMP-dependent protein kinase (cGMP kinase) is the major receptor protein for cGMP
in vascular smooth muscle. Vascular smooth muscle cells (VSMC) isolated from the rat …

In response to nerve growth factor (NGF), clonal pheochromocytoma cells flatten and extend
neurites capable of making functional synapses. Although no significant changes in overall …

… For each of the eight systems, a severity grade (AE) is calculated based on the scores.
Grade A disease is active enough to need treatment. Grade B disease has the potential to need …