… F(ab′… ab′) 2 antivenoms are more effective and safer than whole IgG antivenoms on two
main grounds: (a) by having a lower molecular weight and a larger volume of distribution, F(ab…

G. León, G. Rojas, B. Lomonte and JM Gutiérrez. Immunoglobulin G and F (ab'), polyvalent
antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis …

The ability of two antivenoms to Vipera spp., consisting of Fab (Therapeutic Antibodies), or
of F(ab′) 2 (Zagreb Institute of Immunology) antibody fragments, to neutralize the …

… They are catabolised mainly by the kidney, having a more rapid clearance than F(ab′)2 …
F(ab′)2 fragments display a pharmacokinetic profile intermediate between those of Fab …

… Despite differences in their pharmacokinetic profiles, equine whole IgG and F(ab′) 2
antivenoms show similar efficacy in the neutralization of edema, hemorrhage and myonecrosis …

… Antivenoms are constituted by either whole IgG molecules or the immunoglobulin fragments
F(ab')2 and Fab, obtained by digestion with pepsin and papain, respectively. Differences in …

Fucoidan, a natural polysaccharide extracted from brown seaweed, inhibits the myotoxic
phospholipases A 2 present in the venoms of crotalid snakes. This study evaluated the …

… in Brazil where an antivenom constituted by F(ab′) 2 fragments was administered (n = 31).
… Additionally, patients have IgG antibodies that react both with whole equine IgG and F(ab′) …

… F(ab’)2 fragments or monovalent Fab fragments [16]. Most producers manufacture F(ab’)2 …
digestion of IgG and further purification of F(ab’)2 fragments by various techniques, among …

This work examined the presence of antibodies reacting with human erythrocytes in horse-derived
antivenoms used in the treatment of snakebite envenomations, and assessed the …