Pregnancy Outcomes in Couples with Males Exposed to Longterm Anti-tumor Necrosis Factor- α Inhibitor Therapies: A Prospective Study

Mihaela C Micu; Monika Ostensen; Violeta Bojincă; Oana Șerban; Minodora Mihai; Cristina Suța; Anamaria Ramazan; Luminița Enache; Anca Bobircă; Sergiu F Pătcaș; Romeo Micu; Ruxandra Ionescu

doi:10.3899/jrheum.180588

Pregnancy Outcomes in Couples with Males Exposed to Longterm Anti-tumor Necrosis Factor- α Inhibitor Therapies: A Prospective Study

J Rheumatol. 2019 Sep;46(9):1084-1088. doi: 10.3899/jrheum.180588. Epub 2019 Mar 1.

Authors

Mihaela C Micu^{1

2}, Monika Ostensen^{1

2}, Violeta Bojincă^{1

2}, Oana Șerban^{1

2}, Minodora Mihai^{1

2}, Cristina Suța^{1

2}, Anamaria Ramazan^{1

2}, Luminița Enache^{1

2}, Anca Bobircă^{1

2}, Sergiu F Pătcaș^{1

2}, Romeo Micu^{3

4}, Ruxandra Ionescu^{1

2}

Affiliations

¹ From the Rheumatology Division, 2nd Rehabilitation Department, Rehabilitation Clinical Hospital, Cluj-Napoca; Department of Internal Medicine and Rheumatology, "Sfânta Maria" Hospital, Bucharest; 2nd Internal Medicine Department, Mother and Child Department, and Assisted Reproduction Department, 1st Gynecology Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca; ASTRA Outpatient Clinic, Sibiu; Rheumatology Department, 2nd Internal Medicine Department, "Sf. Apostol Andrei" Emergency County Hospital, Constanța; Clinical Center of Rheumatic Diseases, Bucharest; Department of Internal Medicine and Rheumatology, Dr. I. Cantacuzino Clinical Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Norwegian National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav's Hospital, Trondheim University Hospital, Trondheim; Department of Rheumatology, Sørlandet Sykehus, Kristiansand, Norway.
² M.C. Micu, MD, Rheumatology Division, 2nd Rehabilitation Department, Rehabilitation Clinical Hospital; M. Ostensen, Professor, Norwegian National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav's Hospital, Trondheim University Hospital and Department of Rheumatology, Sørlandet Sykehus; V. Bojincă, Lecturer, Department of Internal Medicine and Rheumatology, "Sfânta Maria" Hospital, Bucharest "Carol Davila" University of Medicine and Pharmacy; O. Șerban, Assistant Professor, 2nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy; M. Mihai, MD, ASTRA Outpatient Clinic; C. Suța, Assistant Professor, Rheumatology Department, 2nd Internal Medicine Department, "Sf. Apostol Andrei" Emergency County Hospital; A. Ramazan, MD, Rheumatology Department, 2nd Internal Medicine Department, "Sf. Apostol Andrei" Emergency County Hospital; L. Enache, Assistant Professor, Clinical Center of Rheumatic Diseases; A. Bobircă, Assistant Professor, Department of Internal Medicine and Rheumatology, Dr I. Cantacuzino Clinical Hospital, Bucharest "Carol Davila" University of Medicine and Pharmacy; S.F. Pătcaș, MD, Mother and Child Department, 1st Gynecology Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy; R. Micu, Associate Professor, Assisted Reproduction Department, 1st Gynecology Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy; R. Ionescu, Professor, Department of Internal Medicine and Rheumatology, "Sfânta Maria" Hospital, Bucharest "Carol Davila" University of Medicine and Pharmacy. Dr. M.C. Micu and Prof. M. Ostensen made equal contributions to this report.
³ From the Rheumatology Division, 2nd Rehabilitation Department, Rehabilitation Clinical Hospital, Cluj-Napoca; Department of Internal Medicine and Rheumatology, "Sfânta Maria" Hospital, Bucharest; 2nd Internal Medicine Department, Mother and Child Department, and Assisted Reproduction Department, 1st Gynecology Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca; ASTRA Outpatient Clinic, Sibiu; Rheumatology Department, 2nd Internal Medicine Department, "Sf. Apostol Andrei" Emergency County Hospital, Constanța; Clinical Center of Rheumatic Diseases, Bucharest; Department of Internal Medicine and Rheumatology, Dr. I. Cantacuzino Clinical Hospital, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Norwegian National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav's Hospital, Trondheim University Hospital, Trondheim; Department of Rheumatology, Sørlandet Sykehus, Kristiansand, Norway. romeomicu@hotmail.com.
⁴ M.C. Micu, MD, Rheumatology Division, 2nd Rehabilitation Department, Rehabilitation Clinical Hospital; M. Ostensen, Professor, Norwegian National Advisory Unit on Pregnancy and Rheumatic Diseases, Department of Rheumatology, St. Olav's Hospital, Trondheim University Hospital and Department of Rheumatology, Sørlandet Sykehus; V. Bojincă, Lecturer, Department of Internal Medicine and Rheumatology, "Sfânta Maria" Hospital, Bucharest "Carol Davila" University of Medicine and Pharmacy; O. Șerban, Assistant Professor, 2nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy; M. Mihai, MD, ASTRA Outpatient Clinic; C. Suța, Assistant Professor, Rheumatology Department, 2nd Internal Medicine Department, "Sf. Apostol Andrei" Emergency County Hospital; A. Ramazan, MD, Rheumatology Department, 2nd Internal Medicine Department, "Sf. Apostol Andrei" Emergency County Hospital; L. Enache, Assistant Professor, Clinical Center of Rheumatic Diseases; A. Bobircă, Assistant Professor, Department of Internal Medicine and Rheumatology, Dr I. Cantacuzino Clinical Hospital, Bucharest "Carol Davila" University of Medicine and Pharmacy; S.F. Pătcaș, MD, Mother and Child Department, 1st Gynecology Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy; R. Micu, Associate Professor, Assisted Reproduction Department, 1st Gynecology Clinic, "Iuliu Hatieganu" University of Medicine and Pharmacy; R. Ionescu, Professor, Department of Internal Medicine and Rheumatology, "Sfânta Maria" Hospital, Bucharest "Carol Davila" University of Medicine and Pharmacy. Dr. M.C. Micu and Prof. M. Ostensen made equal contributions to this report. romeomicu@hotmail.com.

PMID: 30824658
DOI: 10.3899/jrheum.180588

Abstract

Objective: To examine the pregnancy achievement and outcomes in couples in which men with spondyloarthritis (SpA) were exposed to tumor necrosis factor inhibitors (TNFi).

Methods: Information about pregnancies involving fathers with SpA was prospectively collected by 6 Romanian rheumatology centers.

Results: Twenty-seven patients achieved 33 pregnancies and fathered 30 healthy children. Three elective abortions (personal reasons) and no spontaneous abortions, preeclampsia/eclampsia, stillbirths, congenital malformations, or pathologies in the children were recorded. Five patients showed normospermia before and after longterm TNFi treatment.

Conclusion: Pregnancy and child outcomes in male patients with SpA exposed to longterm TNFi therapy were reassuring.

Keywords: FERTILITY; MEN; OFFSPRING; PREGNANCY; TNF INHIBITORS.

MeSH terms

Adolescent
Adult
Aged
Antirheumatic Agents / therapeutic use*
Fathers
Female
Humans
Male
Middle Aged
Paternal Exposure*
Pregnancy
Pregnancy Outcome
Prospective Studies
Spondylarthritis / drug therapy*
Tumor Necrosis Factor Inhibitors / therapeutic use*
Young Adult

Substances

Antirheumatic Agents
Tumor Necrosis Factor Inhibitors