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Page 1
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. Ryan TAJ, et al. Among authors: cheallaigh cn. Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1. Nat Commun. 2023. PMID: 37316487 Free PMC article.
Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment.
Greene C, Connolly R, Brennan D, Laffan A, O'Keeffe E, Zaporojan L, O'Callaghan J, Thomson B, Connolly E, Argue R, Martin-Loeches I, Long A, Cheallaigh CN, Conlon N, Doherty CP, Campbell M. Greene C, et al. Among authors: cheallaigh cn. Nat Neurosci. 2024 Mar;27(3):421-432. doi: 10.1038/s41593-024-01576-9. Epub 2024 Feb 22. Nat Neurosci. 2024. PMID: 38388736 Free PMC article.
Characterisation of the pro-inflammatory cytokine signature in severe COVID-19.
Hawerkamp HC, Dyer AH, Patil ND, McElheron M, O'Dowd N, O'Doherty L, Mhaonaigh AU, George AM, O'Halloran AM, Reddy C, Kenny RA, Little MA, Martin-Loeches I, Bergin C, Kennelly SP, Donnelly SC, Bourke NM, Long A, Sui J, Doherty DG, Conlon N, Cheallaigh CN, Fallon PG. Hawerkamp HC, et al. Among authors: cheallaigh cn. Front Immunol. 2023 Mar 30;14:1170012. doi: 10.3389/fimmu.2023.1170012. eCollection 2023. Front Immunol. 2023. PMID: 37063871 Free PMC article.
Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.
Smith N, Possémé C, Bondet V, Sugrue J, Townsend L, Charbit B, Rouilly V, Saint-André V, Dott T, Pozo AR, Yatim N, Schwartz O, Cervantes-Gonzalez M, Ghosn J, Bastard P, Casanova JL, Szwebel TA, Terrier B, Conlon N, O'Farrelly C, Cheallaigh CN, Bourke NM, Duffy D. Smith N, et al. Among authors: cheallaigh cn. Nat Commun. 2022 Nov 25;13(1):7254. doi: 10.1038/s41467-022-34895-1. Nat Commun. 2022. PMID: 36434007 Free PMC article.
Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, O' Brien EC, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, O' Donnell JS, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, O'Neill LAJ. Ryan TAJ, et al. Among authors: cheallaigh cn. Nat Commun. 2023 Jul 20;14(1):4374. doi: 10.1038/s41467-023-40034-1. Nat Commun. 2023. PMID: 37474527 Free PMC article. No abstract available.
Endothelial cell activation, Weibel-Palade body secretion, and enhanced angiogenesis in severe COVID-19.
Karampini E, Fogarty H, Elliott S, Morrin H, Bergin C, O'Sullivan JM, Byrne M, Martin-Loeches I, Mallon PW, Curley GF, Glavey S, Baker RI, Lavin M, Preston RJS, Cheallaigh CN, Ward SE, O'Donnell JS. Karampini E, et al. Among authors: cheallaigh cn. Res Pract Thromb Haemost. 2023 Feb;7(2):100085. doi: 10.1016/j.rpth.2023.100085. Epub 2023 Feb 14. Res Pract Thromb Haemost. 2023. PMID: 36817284 Free PMC article.
Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression.
Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Hennessy M, Byrne D, Browne P, Bacon CL, Doyle C, O'Riordan R, McLaughlin AM, Bannan C, Martin-Loeches I, White A, McLoughlin RM, Bergin C, Bourke NM, O'Farrelly C, Conlon N, Cheallaigh CN; STAR COVID Bioresource. Townsend L, et al. Among authors: cheallaigh cn. Heliyon. 2022 Apr;8(4):e09230. doi: 10.1016/j.heliyon.2022.e09230. Epub 2022 Apr 1. Heliyon. 2022. PMID: 35386227 Free PMC article.
Sustained VWF-ADAMTS-13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction.
Fogarty H, Ward SE, Townsend L, Karampini E, Elliott S, Conlon N, Dunne J, Kiersey R, Naughton A, Gardiner M, Byrne M, Bergin C, O'Sullivan JM, Martin-Loeches I, Nadarajan P, Bannan C, Mallon PW, Curley GF, Preston RJS, Rehill AM, Baker RI, Cheallaigh CN, O'Donnell JS; Irish COVID-19 Vasculopathy Study (iCVS) Investigators. Fogarty H, et al. Among authors: cheallaigh cn. J Thromb Haemost. 2022 Oct;20(10):2429-2438. doi: 10.1111/jth.15830. Epub 2022 Aug 4. J Thromb Haemost. 2022. PMID: 35875995 Free PMC article.
18 results