Is rheumatoid arthritis a risk factor for oral bisphosphonate-induced osteonecrosis of the jaws?

Nicolau Conte Neto; Alliny de Souza Bastos; Rosemary Adriana Chierici-Marcantonio; Elcio Marcantonio Jr

doi:10.1016/j.mehy.2011.08.008

Is rheumatoid arthritis a risk factor for oral bisphosphonate-induced osteonecrosis of the jaws?

Med Hypotheses. 2011 Nov;77(5):905-11. doi: 10.1016/j.mehy.2011.08.008. Epub 2011 Aug 31.

Authors

Nicolau Conte Neto¹, Alliny de Souza Bastos, Rosemary Adriana Chierici-Marcantonio, Elcio Marcantonio Jr

Affiliation

¹ UNESP-Univ. of Estadual Paulista, Araraquara Dental School, Department of Periodontology, Araraquara, São Paulo, Brazil. conteneto@hotmail.com

PMID: 21885199
DOI: 10.1016/j.mehy.2011.08.008

Abstract

Bisphosphonate-related osteonecrosis of the jaws is a relevant side-effect of these drugs that has been generating a great concern through increasing reports, worldwide, of this bone necrosis. Among several BRONJ hypothetical co-factors that could play a role in BRONJ pathogenesis, rheumatoid arthritis (RA) has been included as a relevant risk factor for BRONJ; however, until now the relationship between these diseases has not been fully explained. Thus, the purpose of this paper is to establish hypothetical factors that could link these two diseases, considering mainly inflammatory components and the organism effects of medicines used to treat RA, particularly steroids and methotrexate (MTX).

MeSH terms

Administration, Oral
Arthritis, Rheumatoid / complications*
Bisphosphonate-Associated Osteonecrosis of the Jaw / complications*
Bone Density Conservation Agents / administration & dosage
Bone Density Conservation Agents / adverse effects*
Humans
Models, Theoretical*
Risk Factors

Substances

Bone Density Conservation Agents