While rheumatoid factor (RF) testing has been previously used in the detection of rheumatoid arthritis (RA), its effectiveness has been limited by poor rates of sensitivity and specificity and its positivity in multiple other disease states. Given its enhanced specificity, quantification of anticyclic-citrullinated protein (anti-CCP) antibodies has emerged as a standard in molecular testing for RA. Despite the importance of this test in clinical rheumatology, we are unaware of any reports of its use in the detection of uveitis or orbital disease. In this report, we characterize the first use of anti-CCP in the diagnosis of orbital disease.