Case history and clinical findings: Two women, aged 71 and 53 years with periprosthetic fractures of the left femur and an 18 year old man with a non-union of fracture of the left radius presented for assessment and treatment.
Investigations: Serial radiographs showed that osteosynthesis and/or autogenous bone-grafting and multiple revisions had not resulted in healing of the fractures.
Treatment and clinical course: In all three patients parathyroid hormone (teriparatide), 20 to 60 microg, was injected subcutaneously once daily for 6 - 10 weeks. Subsequently a stable consolidation of the bone occurred in all of them.
Conclusion: Administration of parathyroid hormone can induce stable consolidation of the bone in non-unions and delayed healing of bone fractures.
Georg Thieme Verlag KG Stuttgart, New York.