Abstract
The signs and symptoms of ankylosing spondylitis (AS) respond inadequately to nonsteroidal antiinflammatory drugs, corticosteroids, and disease modifying antirheumatic drugs in quite a number of patients. Tumor necrosis factor inhibitors have demonstrated to be of value in reducing AS disease activity in clinical trials. The efficacy and safety of both etanercept and infliximab in patients with ankylosing spondylitis were compared in a 2-year open label randomised study. Our results are consistent with a significant more rapid clinical improvement in the infliximab treated group. Treatment with both etanercept and infliximab at the end of the study was effective, safe, and well tolerated.
Publication types
-
Comparative Study
-
Randomized Controlled Trial
MeSH terms
-
Adult
-
Antibodies, Monoclonal / administration & dosage*
-
Antibodies, Monoclonal / adverse effects
-
Antirheumatic Agents / administration & dosage*
-
Antirheumatic Agents / adverse effects
-
Drug Administration Schedule
-
Etanercept
-
Female
-
Humans
-
Immunoglobulin G / administration & dosage*
-
Immunoglobulin G / adverse effects
-
Infliximab
-
Male
-
Outcome Assessment, Health Care / methods
-
Receptors, Tumor Necrosis Factor / administration & dosage*
-
Spondylitis, Ankylosing / drug therapy*
-
Spondylitis, Ankylosing / pathology
-
Treatment Outcome
-
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
-
Antibodies, Monoclonal
-
Antirheumatic Agents
-
Immunoglobulin G
-
Receptors, Tumor Necrosis Factor
-
Tumor Necrosis Factor-alpha
-
Infliximab
-
Etanercept