Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus

J Neuroimmunol. 2009 Jul 25;212(1-2):3-9. doi: 10.1016/j.jneuroim.2009.05.003. Epub 2009 Jun 4.

Abstract

In the course of Systemic Lupus Erythematosus (SLE), a variety of neuropsychiatric disturbances is reported with a prevalence ranging from 17% to 75%. The diagnosis of these syndromes is difficult and requires a careful psychiatric evaluation. Distinct autoantibodies detectable in serum or cerebrospinal fluid of patients with SLE are associated with the presence of neuropsychiatric disorders. These autoantibodies may have a pathogenic relevance in neuropsychiatric SLE or they may be merely an epiphenomenon. This review describes the various autoantibodies reported to be associated with neuropsychiatric manifestations in SLE and discusses their possible role.

Publication types

  • Review

MeSH terms

  • Antibodies, Anticardiolipin / physiology
  • Antibodies, Antinuclear / physiology
  • Autoantibodies / physiology*
  • Endothelial Cells / immunology
  • Gangliosides / immunology
  • Glial Fibrillary Acidic Protein / immunology
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / psychology
  • Mental Disorders / etiology*
  • Microtubule-Associated Proteins / immunology
  • Neurons / immunology
  • Phosphoric Monoester Hydrolases / immunology
  • Receptors, N-Methyl-D-Aspartate / immunology
  • Ribosomes / immunology

Substances

  • Antibodies, Anticardiolipin
  • Antibodies, Antinuclear
  • Autoantibodies
  • Gangliosides
  • Glial Fibrillary Acidic Protein
  • Microtubule-Associated Proteins
  • Receptors, N-Methyl-D-Aspartate
  • SS-A antibodies
  • Phosphoric Monoester Hydrolases