Limitations of a quantitative swollen and tender joint count to assess and monitor patients with rheumatoid arthritis

Bull NYU Hosp Jt Dis. 2008;66(3):216-23.

Abstract

A quantitative count of swollen and tender joints is a primary measure to assess patients with rheumatoid arthritis (RA), and is weighted of higher value than the other 5 Core Data Set measures in all indices in which it is included. However a number of limitations of the swollen and tender joint count have been described in the rheumatology literature, including poor reproducibility, with a requirement to be performed by the same observer at each visit; likelihood to improve with placebo treatment as much or more than the other 5 RA Core Data Set measures in clinical trials; similar or lower relative efficiencies than global and patient measures to document differences between active and control treatments in clinical trials; improvement over 5 years in clinical care, while joint damage and functional disability may progress; and lower sensitivity to detect inflammatory activity than ultrasound. Most visits to a rheumatologist do not include a formal quantitative joint count. It may be suggested that a careful qualitative joint count, supplemented by quantitative patient self-report questionnaire scores, may be more than adequate to monitor and document changes in patient status in busy clinical settings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / pathology*
  • Arthritis, Rheumatoid / physiopathology
  • Arthritis, Rheumatoid / therapy
  • Clinical Trials as Topic
  • Disability Evaluation
  • Disease Progression
  • Humans
  • Joints / pathology*
  • Joints / physiopathology
  • Observer Variation
  • Pain / etiology*
  • Pain / pathology
  • Pain / physiopathology
  • Pain Measurement
  • Predictive Value of Tests
  • Reproducibility of Results
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Treatment Outcome