Treatment of Takayasu's arteritis with tumor necrosis factor antagonists

J Pediatr. 2008 Sep;153(3):432-4. doi: 10.1016/j.jpeds.2008.04.049.

Abstract

Four children with Takayasu's arteritis were treated with tumor necrosis factor antagonists because of disease relapse during conventional therapy or as a first-line agent. Two patients went into remission; in the other 2, the response was partial. Anti-tumor necrosis factor agents can have a role in the treatment of Takayasu's arteritis; further controlled studies are required.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Child
  • Female
  • Follow-Up Studies
  • Humans
  • Infliximab
  • Magnetic Resonance Angiography
  • Male
  • Retrospective Studies
  • Severity of Illness Index
  • Takayasu Arteritis / diagnosis
  • Takayasu Arteritis / drug therapy*
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*

Substances

  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal
  • Tumor Necrosis Factor-alpha
  • Infliximab