Abatacept and serious respiratory infections in patients with previous lung disease

Karla L Miller; Allen D Sawitzke; John Doane

doi:10.1007/s10067-008-0979-9

Abatacept and serious respiratory infections in patients with previous lung disease

Clin Rheumatol. 2008 Dec;27(12):1569-71. doi: 10.1007/s10067-008-0979-9. Epub 2008 Jul 30.

Authors

Karla L Miller¹, Allen D Sawitzke, John Doane

Affiliation

¹ Division of Rheumatology, The University of Utah, School of Medicine, Salt Lake City, UT 84132-2404, USA. karla.miller@hsc.utah.edu

PMID: 18665325
DOI: 10.1007/s10067-008-0979-9

Abstract

Abatacept is a biologic agent used in the treatment of rheumatoid arthritis, for which underlying chronic obstructive lung disease is listed as a precaution to its use due to concern for increased risk of respiratory adverse events. We describe two cases of severe respiratory complications affecting rheumatoid arthritis patients undergoing treatment with abatacept who had been previously diagnosed with underlying lung disease.

Publication types

Case Reports

MeSH terms

Abatacept
Aged
Arthritis, Rheumatoid / complications
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / immunology*
Contraindications
Female
Humans
Immunocompromised Host*
Immunoconjugates / adverse effects*
Immunosuppressive Agents / adverse effects*
Middle Aged
Pneumonia / etiology*
Pulmonary Disease, Chronic Obstructive / complications*

Substances

Immunoconjugates
Immunosuppressive Agents
Abatacept