ROS eliminate danger

Immunity. 2008 Jul 18;29(1):1-2. doi: 10.1016/j.immuni.2008.06.006.

Abstract

Necrotic cells release HMGB1 as a danger signal to activate the immune system. In this issue of Immunity, Kazama et al. (2008) identify a mechanism that determines whether HMGB1 is tolerogenic or immunogenic.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / immunology
  • Dendritic Cells / immunology
  • HMGB1 Protein / immunology*
  • Humans
  • Immune Tolerance*
  • Necrosis / immunology
  • Reactive Oxygen Species / immunology*

Substances

  • HMGB1 Protein
  • Reactive Oxygen Species