Abstract
Necrotic cells release HMGB1 as a danger signal to activate the immune system. In this issue of Immunity, Kazama et al. (2008) identify a mechanism that determines whether HMGB1 is tolerogenic or immunogenic.
MeSH terms
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Animals
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Apoptosis / immunology
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Dendritic Cells / immunology
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HMGB1 Protein / immunology*
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Humans
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Immune Tolerance*
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Necrosis / immunology
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Reactive Oxygen Species / immunology*
Substances
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HMGB1 Protein
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Reactive Oxygen Species