Abstract
A 66-year-old woman who was positive for human T-lymphotropic virus type I (HTLV-I) antibody developed mixed connective tissue disease (MCTD) with interstitial pneumonia, and was successfully treated with corticosteroid. One year later, under maintenance treatment of prednisolone (PSL), she contracted acute type adult Tcell leukemia/lymphoma (ATLL) without flaring of MCTD. MCTD is considered to be as one of the HTL-V-I-related inflammatory diseases, however the development of ATLL during the treatment of HTL-V-I-related MCTD has not been well studied. Here, we review the literature and raise the issue of the mutual interactions between MCTD-causative anti-HTLV-I immune response and anti-ATLL immune response.
MeSH terms
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Aged
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Autoantibodies / blood
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Blotting, Southern
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Fatal Outcome
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Female
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Glucocorticoids / therapeutic use
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Humans
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Immunosuppressive Agents / therapeutic use
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Leukemia-Lymphoma, Adult T-Cell / blood
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Leukemia-Lymphoma, Adult T-Cell / drug therapy
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Leukemia-Lymphoma, Adult T-Cell / immunology*
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Lung Diseases, Interstitial / complications
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Methylprednisolone / therapeutic use
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Mixed Connective Tissue Disease / complications
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Mixed Connective Tissue Disease / diagnosis
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Mixed Connective Tissue Disease / drug therapy*
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Mixed Connective Tissue Disease / immunology
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Prednisolone / therapeutic use
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Receptors, Interleukin-2 / blood
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Thymidine Kinase / blood
Substances
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Autoantibodies
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Glucocorticoids
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Immunosuppressive Agents
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Receptors, Interleukin-2
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Prednisolone
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Thymidine Kinase
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Methylprednisolone