Abstract
Corticosteroid-induced psychosis occurred in 5% of a prospective cohort of 92 patients with systemic lupus erythematosus (SLE). Psychosis was unpredictable by the routes and dosage of corticosteroid used. Factors predictive of psychosis were low serum levels of albumin, complement, and creatinine; history of anxiety disorders; and a family history of psychiatric illnesses. After multivariate adjustment, only hypoalbuminemia remained significant.
MeSH terms
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Adolescent
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Adrenal Cortex Hormones / adverse effects*
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Adrenal Cortex Hormones / therapeutic use
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Adult
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Aged
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Anxiety Disorders / epidemiology
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Causality
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Cohort Studies
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Comorbidity
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Complement C3 / analysis
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Creatinine / blood
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Female
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Follow-Up Studies
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Hong Kong / epidemiology
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Humans
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Hypoalbuminemia / diagnosis
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Hypoalbuminemia / epidemiology*
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Incidence
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Lupus Erythematosus, Systemic / drug therapy*
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Lupus Erythematosus, Systemic / epidemiology
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Male
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Methylprednisolone / adverse effects
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Methylprednisolone / therapeutic use
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Middle Aged
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Predictive Value of Tests
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Prednisone / adverse effects
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Prednisone / therapeutic use
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Prospective Studies
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Psychoses, Substance-Induced / blood
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Psychoses, Substance-Induced / diagnosis*
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Psychoses, Substance-Induced / epidemiology*
Substances
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Adrenal Cortex Hormones
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Complement C3
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Creatinine
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Prednisone
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Methylprednisolone