A patient with soft-tissue sarcoidosis of the hand is described. She initially presented with diffuse soft-tissue infiltration in the digits. After a 12-year time period without steroid treatment the patient developed extensive, tumor-like nodular masses involving multiple digits with lesions extending to the fingertips. Variable clinical features of the soft-tissue sarcoidosis of the hand have been reported as distinctive, independent manifestations of the disease. A transition from the diffuse cellular infiltration to the nodular, tumor-like lesions in the present case shows that the isolated soft-tissue sarcoidosis of the hand may exhibit variable clinical features in a single case.