Abstract
Interleukin-10 (IL-10) is an immunoregulatory cytokine that plays a crucial role in inflammatory and immune reactions. It has potent anti-inflammatory and immunosuppressive activities on myeloid cell functions which forms a solid basis for its use in acute and chronic inflammatory diseases. Here, we discuss the role of IL-10 in autoimmune diseases and examine its beneficial effects in cellular-based autoimmune diseases such as multiple sclerosis (MS) or its involvement in humoral-based autoimmune diseases such as systemic lupus erythematosus (SLE). Inhibition of the immune stimulatory activities of IL-10 may provide novel approaches in the treatment of humoral autoimmune diseases, infectious diseases and cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmune Diseases / immunology
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Autoimmune Diseases / physiopathology*
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B-Lymphocytes / immunology
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Cytokines / physiology
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Disease Models, Animal
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Drug Administration Routes
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Encephalomyelitis, Autoimmune, Experimental / drug therapy
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Encephalomyelitis, Autoimmune, Experimental / physiopathology
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Humans
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Immunologic Factors / therapeutic use
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Interleukin-10 / antagonists & inhibitors
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Interleukin-10 / genetics
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Interleukin-10 / physiology*
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Interleukin-10 / therapeutic use
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Lupus Erythematosus, Systemic / immunology
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Lupus Erythematosus, Systemic / physiopathology*
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Lymphocyte Activation
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Mice
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Mice, Inbred NZB
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Models, Immunological
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Multiple Sclerosis / immunology
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Multiple Sclerosis / physiopathology*
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Polymorphism, Genetic
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Th1 Cells / immunology
Substances
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Cytokines
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Immunologic Factors
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Interleukin-10