Abstract
The active form of vitamin D (1,25-(OH)(2)D(3)) is a potent immune system regulator. In vivo the oral administration of 1, 25-(OH)(2)D(3) completely prevents experimental autoimmune encephalomyelitis (EAE), significantly prolongs allograft survival, and prevents collagen-induced arthritis. 1,25-(OH)(2)D(3) given to mice increased IL-4 protein and transcript levels. We have now tested the efficacy of 1,25-(OH)(2)D(3) on EAE development and allograft survival in IL-4-deficient [knockout (ko)] mice. 1, 25-(OH)(2)D(3) was found to be much less effective in the absence of IL-4, suggesting that IL-4 production is a significant factor in the action of 1,25-(OH)(2)D(3) on the immune system.
Copyright 2000 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Oral
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Animals
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Arthritis / chemically induced
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Arthritis / prevention & control
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Calcitriol / administration & dosage
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Calcitriol / immunology*
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Calcitriol / pharmacology*
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Calcitriol / therapeutic use
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Collagen / pharmacology
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Disease Susceptibility / immunology
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Dose-Response Relationship, Drug
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Encephalomyelitis, Autoimmune, Experimental / genetics
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Encephalomyelitis, Autoimmune, Experimental / mortality
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Encephalomyelitis, Autoimmune, Experimental / prevention & control
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Female
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Gene Deletion
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Graft Survival / drug effects
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Graft Survival / immunology
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H-2 Antigens / immunology
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Interleukin-4 / deficiency
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Interleukin-4 / genetics
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Interleukin-4 / immunology*
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Interleukin-4 / metabolism*
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Mice, Knockout
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Recurrence
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Transplantation, Homologous / immunology
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Up-Regulation / drug effects*
Substances
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H-2 Antigens
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RNA, Messenger
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Interleukin-4
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Collagen
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Calcitriol