Abstract
The rate of congenital malformations after first-trimester exposure to itraconazole was four times higher when ascertained retrospectively than prospectively (13.0 vs 3.2%, p=0.006). Reporting bias in retrospective studies should be acknowledged in interpretation of such data.
MeSH terms
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Abnormalities, Drug-Induced / epidemiology*
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Antifungal Agents / adverse effects*
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Antifungal Agents / therapeutic use
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Belgium
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Bias
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Cohort Studies
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Data Collection / statistics & numerical data*
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Female
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Humans
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Infant, Newborn
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Itraconazole / adverse effects*
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Itraconazole / therapeutic use
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Male
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Pregnancy
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Pregnancy Outcome
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Pregnancy Trimester, First
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Prospective Studies
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Retrospective Studies
Substances
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Antifungal Agents
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Itraconazole