Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
A Case of Organizing Pneumonia Induced by Tocilizumab
Kayoko IkegawaMasayuki HanaokaAtsuhito UshikiHiroshi YamamotoKeishi Kubo
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JOURNAL OPEN ACCESS

2011 Volume 50 Issue 19 Pages 2191-2193

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Abstract

A 66-year-old woman rheumatoid arthritis was treated with methotrexate and tocilizumab. Chest radiography revealed bilateral consolidation of an upper lesion in the lung. Laboratory data indicated a hepatic disorder and increased eosinophils. Transbronchial lung biopsy specimens showed organizing pneumonia. Infection was unfavorable based on culture and PCR. Drug lymphocyte stimulation test showed positive results both for methotrexate and tocilizumab. We were concerned that her pneumonitis was drug-induced. And the symptoms appeared after the infusion of tocilizumab. Here, we report a case of tocilizumab-induced organizing pneumonia.

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© 2011 by The Japanese Society of Internal Medicine
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