Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
High Procalcitonin in a Patient with Drug Hypersensitivity Syndrome
Branka Bonaci-NikolicIvica JeremicMilos NikolicSladjana AndrejevicLidija Lavadinovic
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JOURNAL OPEN ACCESS

2009 Volume 48 Issue 16 Pages 1471-1474

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Abstract

We present a patient who developed carbamazepine (CBZ)-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with high serum procalcitonin (PCT). The presentation (high fever, hepatosplenomegaly, leukocytosis), high PCT and CRP initially suggested sepsis, and he was treated with antibiotics, while CBZ was continued. The rash and hepatitis worsened. After withdrawal of CBZ, corticosteroid therapy was administered and the patient recovered with normalization of PCT. This case demonstrates that PCT may be increased in patients with DRESS. This is the first report of CBZ-induced DRESS associated with high PCT, and the second case of increased PCT in DRESS.

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© 2009 by The Japanese Society of Internal Medicine
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