Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration

Eun-Jung RHEE; Sang-Tai HWANG; Won-Young LEE; Ji-Ho YOON; Byung-Jin KIM; Bum-Soo KIM; Jin-Ho KANG; Man-Ho LEE; Jung-Roe PARK; Ki-Chul SUNG

doi:10.1507/endocrj.K07E-018

ORIGINALS

Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration

Eun-Jung RHEE, Sang-Tai HWANG, Won-Young LEE, Ji-Ho YOON, Byung-Jin KIM, Bum-Soo KIM, Jin-Ho KANG, Man-Ho LEE, Jung-Roe PARK, Ki-Chul SUNG

Author information

Eun-Jung RHEE
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Sang-Tai HWANG
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Won-Young LEE
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Ji-Ho YOON
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Byung-Jin KIM
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Bum-Soo KIM
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Jin-Ho KANG
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Man-Ho LEE
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Jung-Roe PARK
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine
Ki-Chul SUNG
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine

Keywords: Homocysteine, Metabolic syndrome, Insulin resistance, International Diabetes Federation criteria

JOURNAL FREE ACCESS

2007 Volume 54 Issue 6 Pages 995-1002

DOI https://doi.org/10.1507/endocrj.K07E-018

View "Advance Publication" version (December 4, 2007).

Details

Abstract

Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and increased tHcy levels have been reported to be a novel risk factor of atherosclerotic disease. The aim of this study was to assess the association of the metabolic syndrome components with plasma (tHcy) level. Total 722 participants (284 men, 438 women) from the medical checkup program were enrolled in this study. The clinical characteristics and biochemical parameters of the subjects were assessed and the tHcy levels were compared according to the components of metabolic syndrome diagnosed by Adult Treatment Panel (ATP) III guideline and International Diabetes Federation (IDF) criteria. Among the components, groups with larger waist circumference and higher fasting blood glucose levels showed significantly higher tHcy level than the counterparts. Although statistically insignificant, mean concentrations of tHcy was higher in subjects with metabolic syndrome defined by both criteria. In multiple regression analysis, age, sex and systolic blood pressure were the independent determinants of tHcy level. In conclusion, tHcy level was not associated with metabolic syndrome defined by either criteria in Korean subjects.

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