Soluble Triggering Receptor Expressed on Myeloid Cells and the Diagnosis of Pneumonia and Severe Sepsis

 

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ABSTRACT

The triggering receptor expressed on myeloid cells (TREM)-1 is a recently identified molecule involved in the inflammatory response. It belongs to the immunoglobulin superfamily and is expressed on the surface of neutrophils, mature monocytes, and macrophages. The engagement of TREM-1 synergizes with the Toll-like receptors signaling pathway in amplifying the inflammatory response mediated by several microbial components. The expression of the membrane-bound TREM-1 is strongly upregulated on monocytes during sepsis. Besides its membranous form, a soluble counterpart of TREM-1 exists that is specifically released during several infectious processes. The measurement of that soluble form in biological fluids may be useful as a diagnostic tool, especially during severe sepsis and pneumonia. Moreover, the evolutionary pattern of TREM-1 may be interesting during the follow-up of septic patients.

REFERENCES

• 1 Harbarth S, Garbino J, Pugin J, Romand J A, Lew D, Pittet D. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis.  Am J Med. 2003;  7 529-535
  PubMedGoogle Scholar
• 2 Bates D W, Cook E F, Goldman L, Lee T H. Predicting bacteremia in hospitalized patients: a prospective validated model.  Ann Intern Med. 1990;  113 495-500
  PubMedGoogle Scholar
• 3 Brun-Buisson C. The epidemiology of systemic inflammatory response.  Intensive Care Med. 2000;  26(Suppl 1) S64-S74
  CrossrefPubMedGoogle Scholar
• 4 Miller P R, Munn D D, Meredith J W, Chang M C. Systemic inflammatory response syndrome in trauma intensive care unit: who is infected?.  J Trauma. 1999;  47 1004-1008
  PubMedGoogle Scholar
• 5 Bates D W, Sands K, Miller E et al.. Predicting bacteremia in patients with sepsis syndrome. Academic Medical Center Consortium Sepsis Project Working Group.  J Infect Dis. 1997;  176 1538-1551
  PubMedGoogle Scholar
• 6 Birmingham M C, Hassett J M, Schentag J J, Paladino J A. Assessing antibacterial pharmacoeconomics in the intensive care unit.  Pharmacoeconomics. 1997;  12 637-647
  PubMedGoogle Scholar
• 7 Boucher B A, Hanes S D. Searching for simple outcome markers in sepsis: an effort in futility?.  Crit Care Med. 1999;  27 1390-1391
  PubMedGoogle Scholar
• 8 Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection.  Lancet. 1993;  341 515-518
  CrossrefPubMedGoogle Scholar
• 9 Brunkhorst F M, Wegscheider K, Forycki Z F, Brunkhorst R. Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis and septic shock.  Intensive Care Med. 2000;  26 S148-S152
  CrossrefPubMedGoogle Scholar
• 10 Vincent J L. Procalcitonin: the marker of sepsis?.  Crit Care Med. 2000;  28 1226-1228
  PubMedGoogle Scholar
• 11 Ruokonen E, Nousiainen T, Pulkki K, Takala J. Procalcitonin concentrations in patients with neutropenic fever.  Eur J Clin Microbiol Infect Dis. 1999;  27 498-504
  PubMedGoogle Scholar
• 12 Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.  J Immunol. 2000;  164 4991-4995
  PubMedGoogle Scholar
• 13 Colonna M. TREMs in the immune system and beyond.  Nat Rev Immunol. 2003;  3 445-453
  CrossrefPubMedGoogle Scholar
• 14 Bouchon A, Hernandez-Munain C, Cella M, Colonna M A. DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.  J Exp Med. 2001;  194 1111-1122
  CrossrefPubMedGoogle Scholar
• 15 Paloneva J, Manninen T, Christman G et al.. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.  Am J Hum Genet. 2002;  71 656-662
  CrossrefPubMedGoogle Scholar
• 16 Gingras M C, Lapillonne H, Margolin J F. TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.  Mol Immunol. 2002;  38 817-824
  CrossrefPubMedGoogle Scholar
• 17 Washington A V, Quigley L, McVicar D W. Initial characterization of TREM-like transcript (TLT)-1: A putative inhibitory receptor within the TREM cluster.  Blood. 2002;  100 3822-3824
  CrossrefPubMedGoogle Scholar
• 18 Barrow A D, Astoul E, Floto A et al.. Cutting edge: TREM-like transcript, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather inhibits, calcium signaling via SHP-2.  J Immunol. 2004;  172 5838-5842
  PubMedGoogle Scholar
• 19 Washington A V, Schubert R L, Quigley L et al.. TREM family member, TLT-1, is found exclusively in the α-granules of megakaryocytes and platelets.  Blood. 2004;  104 1042-1047
  CrossrefPubMedGoogle Scholar
• 20 Daws M R, Lanier L L, Seaman W E, Ryan J C. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.  Eur J Immunol. 2001;  31 783-791
  CrossrefPubMedGoogle Scholar
• 21 Chung D H, Seaman W E, Daws M R. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig-domain receptors on mouse chromosome.  Eur J Immunol. 2002;  32 59-66
  CrossrefPubMedGoogle Scholar
• 22 Bouchon A, Facchetti F, Weigand M A, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock.  Nature. 2001;  410 1103-1107
  CrossrefPubMedGoogle Scholar
• 23 Gibot S, le Renard P E, Béné M C, Faure G C, Bollaert P E, Levy B. Surface and soluble triggering receptor expressed on myeloid cells-1: expression patterns in murine sepsis.  Crit Care Med. 2005;  , In press
  PubMedGoogle Scholar
• 24 Schenk M, Bouchon A, Birrer S, Colonna M, Mueller C. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine.  J Immunol. 2005;  174 517-524
  PubMedGoogle Scholar
• 25 Radsak M P, Salih H R, Rammensee H G, Schild H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival.  J Immunol. 2004;  172 4956-4963
  PubMedGoogle Scholar
• 26 Knapp S, Gibot S, de Vos A, Versteeg H H, Colonna M, van der Poll T. Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxinemia.  J Immunol. 2004;  173 7131-7134
  CrossrefPubMedGoogle Scholar
• 27 Gibot S, Kolopp-Sarda M N, Béné M C et al.. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis.  J Exp Med. 2004;  200 1419-1426
  CrossrefPubMedGoogle Scholar
• 28 Gibot S, le Renard P E, Bollaert P E et al.. Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock.  Intensive Care Med. 2005;  31 594-597
  CrossrefPubMedGoogle Scholar
• 29 Gibot S, Cravoisy A, Levy B, Béné M C, Faure G C, Bollaert P E. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia.  N Engl J Med. 2004;  350 451-458
  CrossrefPubMedGoogle Scholar
• 30 Determann R, Millo J, Gibot S et al.. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during the development of ventilator-associated pneumonia.  Intensive Care Med. 2005;  31 1495-1500
  CrossrefPubMedGoogle Scholar
• 31 Horonenko G, Robbins R A, Singarajah C U, Hayden J M, Ballering J, Hoyt J C. Human soluble triggering receptor expressed on myeloid cells can be detected in exhaled breath condensate and correlates with ventilator associated pneumonia. American Thoracic Society, San Diego; 2005 Abst A85
  Google Scholar
• 32 Richeldi L, Mariani M, Losi M et al.. Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections.  Eur Respir J. 2004;  24 247-250
  CrossrefPubMedGoogle Scholar
• 33 Gibot S, Kolopp-Sarda M N, Béné M C et al.. Plasma level of a triggering receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis.  Ann Intern Med. 2004;  141 9-15
  PubMedGoogle Scholar
• 34 Gibot S, Cravoisy A, Kolopp-Sarda M N et al.. Time-course of soluble TREM-1, procalcitonin and C-reactive protein plasma concentrations during sepsis.  Crit Care Med. 2005;  33 792-796
  CrossrefPubMedGoogle Scholar

Sébastien GibotM.D. Ph.D. 

Service de Réanimation Médicale, 29 avenue du Maréchal de Lattre de Tassigny, Hôpital Central

54035 Nancy Cedex, France

Email: s.gibot@chu-nancy.fr