Original InvestigationPathogenesis and Treatment of Kidney DiseaseModification of the Modification of Diet in Renal Disease (MDRD) Study Equation for Japan
Section snippets
Methods
We followed 5 steps to obtain an equation that accurately estimates GFR for Japanese patients with CKD.
Creatinine Calibration
Results of creatinine calibration in the 3 laboratories are shown in Table 1 and Fig 1. For 40 reference samples of the calibration panel, values obtained by means of enzymatic methods in the central and TWMU laboratories highly correlated with values assigned by the Cleveland Clinic based on nonsignificant laboratory-specific linear regression intercepts and slopes close to 1. Creatinine values for the central laboratory and TWMU laboratory were not adjusted, although the regression slope for
Discussion
The goal of the study is to establish an equation of accurate GFR estimation for Japanese patients with CKD. Applying the JSN-CKDI coefficient, the modified IDMS MDRD Study equation improved GFR estimation in patients with CKD. The JSN-CKDI equation also provided significantly more accurate GFRs than the original 4-variable IDMS MDRD Study equation. At present, we propose that the modified IDMS MDRD Study equation using the JSN-CKDI coefficient (equation 1) and the JSN-CKDI equation (equation
Acknowledgements
We thank Dr Lesley A. Stevens for critical reading of the manuscript and kind efforts in coordinating the exchange of samples with Dr Van Lente’s laboratory and Drs Shigeko Hara, Toshiki Moriyama, Yasuhiro Ando, Hideki Hirakata, Tsuyoshi Watanabe, Kenji Wakai, Ichiei Narita, Yutaka Kiyohara, and Yoshinari Yasuda for helpful discussions. Fuji Yakuhin Co Ltd provided data from the Cin clinical trial.
Support: None.
Financial Disclosure: None.
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