Original InvestigationPathogenesis and Treatment of Kidney DiseaseClinical and Pathological Features of Renal Involvement in Propylthiouracil-Associated ANCA-Positive Vasculitis
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Clinical and laboratory data and kidney biopsy results of patients with PTU-associated ANCA-positive vasculitis with renal involvement who were diagnosed in Peking University First Hospital from December 1999 to December 2005 were reviewed retrospectively. PTU-associated ANCA-positive vasculitis was defined by the following characteristics: (1) signs and symptoms of vasculitis were related closely to PTU administration and regressed with its discontinuation, (2) positive serum ANCA result
Demographic Features of Patients With PTU-Associated ANCA-Positive Vasculitis
There were 19 patients with PTU-associated ANCA-positive vasculitis and 15 patients (80%) with renal involvement (Table 1). They were administered PTU for Graves disease. Duration of PTU administration was 43.0 ± 31.2 months (1.5 to 96 months). Of 15 patients with renal involvement, 13 were female and 2 were male, with an average age of 26.3 ± 11.8 years (11 to 57 years). Sera from all 15 patients were perinuclear ANCA positive, but cytoplasmic ANCA was not detected in any patient. Sera from
Discussion
ANCA can be shown at some time in about 6% to 63% of patients treated with PTU, but at most, full-blown vasculitis will be diagnosed in 20% of individuals administered PTU and with PTU-associated ANCA.18, 19, 20, 21 Clinical and pathological characteristics of renal involvement and renal outcome in patients with PTU-associated ANCA-positive vasculitis are not well described.
Renal involvement in patients with PTU-associated ANCA-positive vasculitis as reported in the literature ranged from 58%
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Old known and possible new biomarkers of ANCA-associated vasculitis
2022, Journal of AutoimmunityCitation Excerpt :Finally, the biological role of pentraxin-3 antibodies also remains unclear. Thus, although the determination of these antibodies could be useful as a biomarker for disease diagnosis in a subset of AAV patients, it requires further pathophysiological investigation and external validation [64–79]. An increase in erythrocyte sedimentation rate (ESR) and/or C-reactive protein (CRP) is characteristic of an active, generalized disease, and usually correlate with AAV disease activity.
Comorbidities and health-related quality of life in Patients with Antineutrophil Cytoplasmic Antibody (ANCA) - associated vasculitis
2021, Autoimmunity ReviewsCitation Excerpt :Compared to primitive-AAV, PTU-induced AAV is often less severe, with fewer organs affected and with less severe kidney damage. It has a better overall and renal prognosis [67–69], often with regression simply on stopping PTU [59,70]. Nevertheless, there are severe forms, sometimes with progression to death or end-stage renal disease, justifying conventional immunosuppressive drugs [59,71–73].
The Complement System
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2024, Rheumatology (United Kingdom)Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Overlap IgA Nephropathy: A Case Report
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Originally published online as doi:10.1053/j.ajkd.2007.01.021 on March 1, 2007.
Support: National Natural Science Fund (No. 30500459) and a grant from the Chinese 985 Project (985-2-033-39). Potential conflicts of interest: None.