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Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit

Genes & Immunity volume 1, pages 515–520 (2000)Cite this article

Abstract

Owing to the importance of interleukin (IL)-12 in regulating immune responses, we have determined the complete genomic sequence and organization of the gene encoding its p40 subunit. The genomic sequence was determined and was compared to cDNA sequences to derive exon/intron boundaries. Unusually, both the first and last of the eight exons of this gene are not translated. An extensive search identified several polymorphisms in IL-12p40, including repeat elements in introns 2 and 4 and a polymorphic TaqI site in the 3′UTR. However, no polymorphisms were found which could result in amino acid substitutions. This finding places constraints on any preferential involvement of alleles of IL-12p40 in contributing to autoimmune, inflammatory or infectious diseases.

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Authors and Affiliations

  1. Complex Genetic Diseases Laboratory, and Cooperative Research Centre for Discovery of Genes for Common Human Diseases, The Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, 3050, Australia

    D Huang, MR Cancilla & G Morahan

Authors
  1. D Huang
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  2. MR Cancilla
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  3. G Morahan
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Corresponding author

Correspondence to G Morahan.

Additional information

This work was supported by the National Health & Medical Research Council of Australia and by the Juvenile Diabetes Foundation International. The CRC for Discovery of Genes for Common Human Diseases is established and supported by the Australian Government’s Cooperative Research Centre’s Program.

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Huang, D., Cancilla, M. & Morahan, G. Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun 1, 515–520 (2000). https://doi.org/10.1038/sj.gene.6363720

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  • DOI: https://doi.org/10.1038/sj.gene.6363720

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