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Successes, challenges and developments in Australian rheumatology

Abstract

Australia is a geographically vast but sparsely populated country with many unique factors affecting the practice of rheumatology. With a population comprising minority Indigenous peoples, a historically European-origin majority population, and recent large-scale migration from Asia, the effect of ethnic diversity on the phenotype of rheumatic diseases such as systemic lupus erythematosus (SLE) is a constant of Australian rheumatology practice. Australia has a strong system of universal healthcare and subsidized access to medications, and clinical and research rheumatology are well developed, but inequitable access to specialist care in urban and regional centres, and the complex disconnected structure of the Australian healthcare system, can hinder the management of chronic diseases.

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Figure 1: Disconnection in the Australian healthcare system—a model solution.
Figure 2: The Australian rheumatology workforce.
Figure 3: Rheumatology services in Victoria, Australia.

References

  1. Beach, W. G. The Australian Federal constitution. Polit. Sci. Q. 14, 663–680 (1899).

    Article  Google Scholar 

  2. Selway, B. & Williams, J. M. The High Court and Australian Federalism. Publius 35, 467–488 (2005).

    Article  Google Scholar 

  3. Willis, E., Reynolds, L. & Keleher, H. (Ed.) Understanding the Australian Health Care System (Elsevier Health Sciences, 2009).

    Google Scholar 

  4. OECD. Health at a glance–OECD indicators [online], (2013).

  5. Zhang, M., Holman, C. D., Preen, D. B. & Brameld, K. Repeat adverse drug reactions causing hospitalization in older Australians: a population-based longitudinal study 1980–2003. Br. J. Clin. Pharmacol. 63, 163–170 (2007).

    Article  Google Scholar 

  6. Lehnbom, E. C., McLachlan, A. & Brien, J. A. A qualitative study of Australians' opinions about personally controlled electronic health records. Stud. Health Technol. Inform. 178, 105–110 (2012).

    PubMed  Google Scholar 

  7. Henry, D. A., Hill, S. R. & Harris, A. Drug prices and value for money: the Australian Pharmaceutical Benefits Scheme. JAMA 294, 2630–2632 (2005).

    Article  CAS  Google Scholar 

  8. Drummond, M., Jonsson, B. & Rutten, F. The role of economic evaluation in the pricing and reimbursement of medicines. Health Policy 40, 199–215 (1997).

    Article  CAS  Google Scholar 

  9. Morgan, S. G. et al. Centralized drug review processes in Australia, Canada, New Zealand, and the United Kingdom. Health Aff. (Millwood) 25, 337–347 (2006).

    Article  Google Scholar 

  10. Bloor, K., Maynard, A. & Freemantle, N. Lessons from international experience in controlling pharmaceutical expenditure. III: regulating industry. BMJ 313, 33–35 (1996).

    Article  CAS  Google Scholar 

  11. Duckett, S., Breadon, P., Ginnivan, L. & Nolan, J. Poor pricing progress: price disclosure isn't the answer to high drug prices. Grattan Institute website [online], (2013).

    Google Scholar 

  12. Deal, C. L. et al. The United States rheumatology workforce: supply and demand, 2005–2025 Arthritis Rheum. 56, 722–729 (2007).

    Article  Google Scholar 

  13. Deal, C. L. The regional distribution of rheumatologists: what can we do, what should we do? Arthritis Rheum. 65, 3011–3013 (2013).

    Article  Google Scholar 

  14. Arthritis Victoria. Arthritis Map: Victorian musculoskeletal community directory [online] (2015).

  15. Chondur, R., Li, S. Q., Guthridge, S. & Lawton, P. Does relative remoteness affect chronic disease outcomes? Geographic variation in chronic disease mortality in Australia, 2002–2006. Aust. N. Z. J. Public Health 38, 117–121 (2014).

    Article  Google Scholar 

  16. Zhang, F. The China rheumatology workforce: a status report. Int. J. Rheum. Dis. 12, 279–282 (2009).

    Article  CAS  Google Scholar 

  17. Jakes, R. W. et al. Systematic review of the epidemiology of systemic lupus erythematosus in the Asia-Pacific region: prevalence, incidence, clinical features, and mortality. Arthritis Care Res. (Hoboken) 64, 159–168 (2012).

    Article  Google Scholar 

  18. Freemantle, J. et al. Indigenous mortality (revealed): The Invisible illuminated. Am. J. Public Health, e1–e9 (2014).

  19. Gao, X. & Serjeantson, S. W. Diversity in HLA-DR4-related, DR, DQ haplotypes in Australia, Oceania, and China. Hum. Immunol. 32, 269–276 (1991).

    Article  CAS  Google Scholar 

  20. Roberts-Thomson, K. F. et al. Prevalence, extent and severity of severe periodontal destruction in an urban Aboriginal and Torres Strait Islander population. Aust. Dent. J. 59, 43–47 (2014).

    Article  CAS  Google Scholar 

  21. Khan, M. A. HLA-B27 and its subtypes in world populations. Curr. Opin. Rheum. 7, 263–269 (1995).

    Article  CAS  Google Scholar 

  22. Roberts-Thomson, R. A. & Roberts-Thomson, P. J. Rheumatic disease and the Australian aborigine. Ann. Rheum. Dis. 58, 266–270 (1999).

    Article  CAS  Google Scholar 

  23. Chang, J. H., Raju, R., Henderson, T. R. & McCluskey, P. J. Incidence and pattern of acute anterior uveitis in Central Australia. Br. J. Ophthalmol. 94, 154–156 (2010).

    Article  CAS  Google Scholar 

  24. Vincent, F. B., Bourke, P., Morand, E. F., Mackay, F. & Bossingham, D. Focus on systemic lupus erythematosus in Indigenous Australians: towards a better understanding of autoimmune diseases. Intern. Med. J. 43, 227–234 (2013).

    Article  CAS  Google Scholar 

  25. Anstey, N. M., Bastian, I., Dunckley, H. & Currie, B. J. Systemic lupus erythematosus in Australian aborigines: high prevalence, morbidity and mortality. Aust. N. Z. J. Med. 23, 646–651 (1993).

    Article  CAS  Google Scholar 

  26. Bossingham, D. Systemic lupus erythematosus in the far north of Queensland. Lupus 12, 327–331 (2003).

    Article  CAS  Google Scholar 

  27. Grennan, D. M. & Bossingham, D. Systemic lupus erythematosus (SLE): different prevalences in different populations of Australian aboriginals. Aust. N. Z. J. Med. 25, 182–183 (1995).

    Article  CAS  Google Scholar 

  28. Segasothy, M. & Phillips, P. A. Systemic lupus erythematosus in Aborigines and Caucasians in central Australia: a comparative study. Lupus 10, 439–444 (2001).

    Article  CAS  Google Scholar 

  29. Bloor, G., Rigby, R. J., Richmond, J. M., Zilko, P. J. & Dawkins, R. L. Systemic lupus erythematosus in Australian Aborigines. Aust. N. Z. J. Med. 12, 553 (1982).

    Google Scholar 

  30. Stewart, J. H., McCredie, M. R. & McDonald, S. P. The incidence of treated end-stage renal disease in New Zealand Maori and Pacific Island people and in Indigenous Australians. Nephrol. Dial. Transplant. 19, 678–685 (2004).

    Article  Google Scholar 

  31. Ranford, P., Hay, J., Serjeantson, S. W. & Dunckley, H. A high frequency of inherited deficiency of complement component C4 in Darwin Aborigines. Aust. N. Z. J. Med. 17, 420–423 (1987).

    Article  CAS  Google Scholar 

  32. Anstey, N. M., Bastian, I., Dunckley, H. & Currie, B. J. Systemic lupus erythematosus (SLE): different prevalences in different populations of Australian aborigines. Aust. N. Z. J. Med. 25, 736 (1995).

    Article  CAS  Google Scholar 

  33. Connelly, K., Morand, E. F. & Hoi, A. Y. Asian ethnicity in systemic lupus erythematosus: an Australian perspective. Intern. Med. J. 43, 618–624 (2013).

    Article  CAS  Google Scholar 

  34. Golder, V., Connelly, K., Staples, M., Morand, E. & Hoi, A. Association of Asian ethnicity with disease activity in SLE: an observational study from the Monash Lupus Clinic. Lupus 22, 1425–1430 (2013).

    Article  CAS  Google Scholar 

  35. The Times. The World University Rankings [online], http://www.timeshighereducation.co.uk/world-university-rankings/2014-15/world-ranking (2014).

  36. Scally, S. W. et al. A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J. Exp. Med. 210, 2569–2582 (2013).

    Article  CAS  Google Scholar 

  37. Vincent, F. B., Morand, E. F., Schneider, P. & Mackay, F. The BAFF/APRIL system in SLE pathogenesis. Nat. Rev. Rheumatol. 10, 365–373 (2014).

    Article  CAS  Google Scholar 

  38. Wellcome Trust Case Control Consortium et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat. Genet. 39, 1329–1337 (2007).

  39. Cornish, A. L., Campbell, I. K., McKenzie, B. S., Chatfield, S. & Wicks, I. P. G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis. Nat. Rev. Rheumatol. 5, 554–559 (2009).

    Article  CAS  Google Scholar 

  40. Ayoub, S., Hickey, M. J. & Morand, E. F. Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis. Nat. Clin. Pract. Rheumatol. 4, 98–105 (2008).

    Article  CAS  Google Scholar 

  41. Hoi, A. Y. et al. Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice. J. Immunol. 177, 5687–5696 (2006).

    Article  CAS  Google Scholar 

  42. Buchbinder, R. et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N. Engl. J. Med. 361, 557–568 (2009).

    Article  CAS  Google Scholar 

  43. Jones, G. et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann. Rheum. Dis. 69, 88–96 (2010).

    Article  CAS  Google Scholar 

  44. Teichtahl, A. J. et al. Weight change and change in tibial cartilage volume and symptoms in obese adults. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-204488.

  45. Ebeling, P. R. et al. Effects of calcitriol or calcium on bone mineral density, bone turnover, and fractures in men with primary osteoporosis: a two-year randomized, double blind, double placebo study. J. Clin. Endocrinol. Metab. 86, 4098–4103 (2001).

    Article  CAS  Google Scholar 

  46. Osthoff, M. et al. Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case inverted question markcontrol and cohort study. Arthritis Res. Ther. 16, 480 (2014).

    Article  Google Scholar 

  47. Morrisroe, K. B. et al. The association of antiphospholipid antibodies with cardiopulmonary manifestations of systemic sclerosis. Clin. Exp. Rheumatol. 32 (6 Suppl. 86) S133–S137 (2014).

    Google Scholar 

  48. Thakkar, V., Stevens, W. M., Moore, O. A. & Nikpour, M. Performance of screening algorithms in systemic sclerosis-related pulmonary arterial hypertension: a systematic review. Intern. Med. J. 43, 751–760 (2013).

    Article  CAS  Google Scholar 

  49. Franklyn, K., Hoi, A., Nikpour, M. & Morand, E. F. The need to define treatment goals for systemic lupus erythematosus. Nat. Rev. Rheumatol. 10, 567–571 (2014).

    Article  CAS  Google Scholar 

  50. Morand, E. F. et al. Consensus definition and preliminary validation of a low disease activity state in systemic lupus erythematosus. Arthritis and Rheum. 65, S664–S665 (2013).

    Google Scholar 

  51. Zborovski, S., Rohekar, G. & Rohekar, S. Strategies to improve recruitment into rheumatology: results of the Workforce in Rheumatology Issues Study (WRIST). J. Rheumatol 37, 1749–1755 (2010).

    Article  Google Scholar 

  52. Rahbar, L. et al. Correlation of rheumatology subspecialty choice and identifiable strong motivations, including intellectual interest. Arthritis Care Res. (Hoboken) 62, 1796–1804 (2010).

    Article  CAS  Google Scholar 

  53. McDonald, F. S., West, C. P., Popkave, C. & Kolars, J. C. Educational debt and reported career plans among internal medicine residents. Ann. Intern. Med. 149, 416–420 (2008).

    Article  Google Scholar 

  54. Frintner, M. P., Mulvey, H. J., Pletcher, B. A. & Olson, L. M. Pediatric resident debt and career intentions. Pediatrics 131, 312–318 (2013).

    Article  Google Scholar 

  55. Alarcon, G. S. & Amigo, M. C. The impact of women in the practice of academic and clinical rheumatology in the Americas. J. Rheumatol. 27, 1827–1829 (2000).

    CAS  PubMed  Google Scholar 

  56. Hordern, A. et al. Use of an electronic drug monitoring system for ambulatory patients with chronic disease: how does it impact on nurses' time spent documenting clinical care? Stud. Health Technol. Inform. 178, 71–76 (2012).

    PubMed  Google Scholar 

  57. Bourne, A. M., Whittle, S. L., Richards, B. L., Maher, C. G. & Buchbinder, R. The scope, funding and publication of musculoskeletal clinical trials performed in Australia. Med. J. Aust. 200, 88–91 (2014).

    Article  Google Scholar 

  58. Herbert, D. L., Barnett, A. G. & Graves, N. Funding: Australia's grant system wastes time. Nature 495, 314 (2013).

    Article  CAS  Google Scholar 

  59. National Health and Medical Research Council of Australia. Outcome of funding rounds [online], (2014).

  60. Morgan, B. Australia reworks research philanthropy to fill unmet need. Nat. Med. 16, 730 (2010).

    Article  CAS  Google Scholar 

  61. Arthritis Research Council UK. Annual report and financial statements [online], (2014).

  62. Arthritis Australia. A year in review 2013–2014 [online], (2014).

  63. Yedidia, M. J. & Bickel, J. Why aren't there more women leaders in academic medicine? The views of clinical department chairs. Acad. Med. 76, 453–465 (2001).

    Article  CAS  Google Scholar 

  64. Office of the Chief Scientist, Commonwealth of Australia. Benchmarking Australian science, technology, engineering and mathematics [online], (2014).

  65. Tymms, K. et al. Barriers to optimal disease control for rheumatoid arthritis patients with moderate and high disease activity. Arthritis Care Res. (Hoboken) 66, 190–196 (2014).

    Article  CAS  Google Scholar 

  66. Littlejohn, G. et al. A multi-center, observational study shows high proportion of Australian rheumatoid arthritis patients have inadequate disease control. Int. J. Rheum. Dis. 16, 532–538 (2013).

    Article  CAS  Google Scholar 

  67. Bird, P. et al. The SMILE study safety of methotrexate in combination with leflunomide in rheumatoid arthritis. J. Rheumatol. 40, 228–235 (2013).

    Article  CAS  Google Scholar 

  68. Curran, V. & Rourke, J. The role of medical education in the recruitment and retention of rural physicians. Med. Teach. 26, 265–272 (2004).

    Article  Google Scholar 

  69. Gruen, R. L., Weeramanthri, T. S. & Bailie, R. S. Outreach and improved access to specialist services for indigenous people in remote Australia: the requirements for sustainability. J. Epidemiol. Community Health 56, 517–521 (2002).

    Article  CAS  Google Scholar 

  70. Moffatt, J. J. & Eley, D. S. Barriers to the up-take of telemedicine in Australia-a view from providers. Rural Remote Health 11, 1581 (2011).

    PubMed  Google Scholar 

  71. Moffatt, J. J. & Eley, D. S. The reported benefits of telehealth for rural Australians. Aust. Health Rev. 34, 276–281 (2010).

    Article  Google Scholar 

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Acknowledgements

The opinions expressed in this article are ours, and do not necessarily reflect the views of the Asia–Pacific League of Associations for Rheumatology (APLAR), the Australian Rheumatology Association (ARA), the International League of Associations for Rheumatology (ILAR) or the Australian government.

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E.F.M. researched data for the article. Both authors contributed to discussion of content, writing and review/editing of the manuscript before submission.

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Correspondence to Eric F. Morand.

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Morand, E., Leech, M. Successes, challenges and developments in Australian rheumatology. Nat Rev Rheumatol 11, 430–436 (2015). https://doi.org/10.1038/nrrheum.2015.22

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